WEEKLY UPDATE: October 17, 2019
SUMMARY: Identification of 5 novel genetic loci correlated to a person’s risk of developing late-onset Alzheimer’s disease.
DESCRIPTION: Alzheimer’s disease is a common cause of dementia, characterized by the degeneration of brain cells. Late-onset Alzheimer’s is the most typical form of Alzheimer’s disease and typically results in the progressive impairment of cognitive abilities. Heredity is known to have a component in determining a person’s risk of developing Alzheimer’s disease. By examining the genetic information of nearly 95,000 participants of European descent, this study identified 5 new variants that appear to correlate with an individual’s risk of developing late-onset Alzheimer’s disease. Some of these variants are located near genes that may affect the accumulation of proteins that disrupt brain function. Other variants are in proximity of genes that are thought to be involved in the functioning of the immune system. Collectively, these variants explain an estimated 7% of the heritability for late-onset Alzheimer’s disease.
DID YOU KNOW? Chronic stress can harm areas of the brain related to memory, and increase a person’s risk of Alzheimer’s disease. Relaxing activities such as breathing exercises, mediation, and yoga can help manage stress. [SOURCE]
ANALYZED VARIANTS: rs429358, rs6733839, rs3851179, rs4844610, rs9331896, rs7933202, rs3752246, rs75932628, rs73223431, rs3740688, rs11218343, rs9271058, rs7920721, rs9473117, rs10808026, rs12539172, rs17125924, rs10933431, rs138190086, rs593742, rs12881735, rs7185636, rs2830500, rs6024870
Alzheimer’s Disease (Video)