WEEKLY UPDATE: January 23, 2020
SUMMARY: Prediction of atrial fibrillation risk using 5 genetic variants.
OVERVIEW: Atrial fibrillation (AFib) is an irregular heartbeat that is much faster than normal. It occurs when the two upper chambers of the heart beat out of sync with the lower chambers. This typically causes weakness and shortness of breath. This study sought to combine genetic and clinical factors to predict the risk of AFib in over 1000 individuals of Japanese descent. Confirming previous research, the researchers identified 5 genetic variants associated with AFib. The study determined a 4.92-fold difference in AFib risk between the highest and lowest polygenic scores that were calculated based on these variants. The risk estimate became more accurate if clinical factors were considered as well.
DID YOU KNOW? The latest iterations of the Apple Watch can detect atrial fibrillation. [SOURCE]
ANALYZED VARIANTS: rs6817105, rs2106261, rs6057225, rs3903239, rs7698692