best-dna-test

Complete guide to the best DNA test kit and other home tests

Which DNA test is right for you? Learn more in our complete guide to the best DNA test kit and other home tests!

Best DNA tests

Best ancestry DNA tests for Discovering your ancestry and connecting with relatives

  1. Nebula Genomics / FamilyTreeDNA
  2. AncestryDNA
  3. 23andMe

Others: African Ancestry, MyHeritage, CRI Genetics, WeGene

Nebula Genomics/FamilyTree

Summary

Nebula Genomics uses comprehensive 30X Whole Genome Sequencing to decode 100% of customer DNA. As a result, they produce 10,000 times more data than other DNA tests like 23andMe and AncestryDNA, meaning that customers can access deep genetic explorations of their ancestry. Consequently, Nebula Genomics provides a detailed ancestry breakdown. 

In collaboration with FamilyTreeDNA, Nebula Genomics provides access to the world’s largest Y-DNA and mtDNA databases. These tests enable customers to trace paternal and maternal lines, respectively. Therefore, tracing these lines results in key genealogy information, such as ancestral migration patterns, the discovery of relatives through DNA matching, and the development of a family tree by discovering new family connections. Above all, by using Nebula Genomics and FamilyTreeDNA, customers can explore more of their family tree and ancestry origins than ever before. 

Reporting
  • Explore: all possible geographical regions that checked for ancestry
  • My Data: breakdown of ancestral heritage, including percentage of heritage from regions that were discovered by sequencing
  • Y-DNA testing analysis (males only): paternal family lineage discovery 
  • mtDNA testing analysis (males and females): maternal lineage discovery 
Cost
  • DNA uploads from AncestryDNA and 23andMe DNA kits – free
  • 30X Whole Genome Sequencing – $0 – $299
Nebula Genomics and FamilyTree logo

AncestryDNA

Summary

AncestryDNA (Ancestry) was one of the first direct-to-consumer DNA testing companies and often thought of as the best ancestry DNA test.  It remains one of the most popular. Their flagship product, AncestryDNA, combines genetic testing with family history exploration. The company uses an autosomal testing service that samples 700,000 genetic  markers in the human genome, providing insight into the user’s ethnicity and where their ancestors lived. 

AncestryDNA includes extensive geneology exploration tools, including DNA matching with relatives, digital family trees, and historical records. As of this reporting, over 18 million people in 30 countries have used an Ancestry product. This large usage group makes Ancestry one of the best ancestry DNA tests for finding as many relatives as possible. 

A downside of Ancestry DNA is that a subscription service is required to access historical data and genealogy tools. With regards to their sequencing technique, the DNA testing technology used by Ancestry covers only a small amount of the human genome, leaving much genetic information undiscovered. 

Reporting
  • Ethnicity estimates from over 1,000 regions around the globe
  • AncestryDNA matches with living relatives who share certain parts of your genetic makeup
  • Family trees and historical records (membership only)
Cost
  • AncestryDNA test – $99
  • Sales often available that save up to 50%
  • Membership – $24.99/month for access to U.S. records and $39.99/month for access to international records
  • Ancestry DNA test + traits – $119
AncestryDNA testing kit

23andMe

Summary

23andMe (23 and Me) made headlines as one of the first direct-to-consumer DNA testing companies to give customers access to their genetic information without professional medical consultation. Like AncestryDNA, it remains one of the most popular direct-to-consumer DNA tests. As of this reporting, 23 and Me has over 10 million users and the second largest user DNA database for ancestry exploration. 

To analyze DNA tests, 23 and Me relies on Y-DNA (Y Chromosome), mtDNA (mitochondrial DNA), and autosomal DNA testing. 23 and Me hosts less information on historical records than AncestryDNA, but includes trait analysis in their basic package.  

23 and Me sells three DNA tests, all including ancestry analysis:

  • Ancestry + traits
  • Health + ancestry
  • VIP health + ancestry

The trait analysis provides customers with information as to how non-medial genetic characteristics, like eye color and taste preference, originate. In addition, the health versions of the 23 and Me DNA test also include health reports that use a customer’s DNA to determine risk of genetic diseases. 

Reporting
  • Ancestry composition
  • Ancestry origin based on male and female haplogroups 
  • Neanderthal ancestry
  • DNA relative finder
  • Traits
  • Health predispositions (Health only)
  • Wellness (Health only)
  • Carrier status (Health only)
Cost
  • Ancestry + traits – $99
  • Health + ancestry – $199
  • VIP health + ancestry – $499
23andMe ancestry testing kit

Best DNA test kit for Improving your diet and finding the right exercise plan

  1. DNAFit
  2. Vitagene
  3. GenoPalate

Others: Fitness Genes, Athletigen, Orig3n

DNAFit

Summary

DNAfit analyzes specific genes related to health and fitness to create personalized diet and fitness plans. The most useful aspect of DNAfit’s Diet Fit DNA kit is their actionable nutritional information, such as personalized meal plans. An extended Health Fit DNA kit also includes predispositions to aspects of exercise and recommendations for training programs. Although customers can upload raw data from other DNA testing sites such as Ancestry, 23andMe, and MyHeritage, this is a paid DNA testing service and they will only receive the limited genetic information on health and nutrition. 

The plan includes a 30 minute support call from a dietician coach and access to the helpful MealPlanner app. DNAfit does not offer whole genome sequencing. However, they have a partnership with CircleDNA, which sells a whole exome sequencing test for customers who want a more comprehensive report of their genome. 

Reporting (Diet)
  • Optimal diet type
  • Carbohydrate and saturated fat sensitivity
  • Detoxification ability
  • Anti-oxidant requirements
  • Personal vitamins and micronutrient needs
  • Salt, alcohol, and caffeine sensitivity
  • Lactose intolerance
  • Coeliac predisposition
Reporting (Health)
  • All the features of the Diet reporting
  • Endurance/Power profile
  • Aerobic potential
  • Post exercise recovery
  • Recovery nutrition
  • Injury risk
Cost
  • Diet Fit – $189
  • Health Fit – $249
  • Circle Premium – $629
DNAFit testing kit

Vitagene

Summary

Vitagene is a DNA testing company that uses a customer’s DNA to produce personalized diet and lifestyle plans. Customers can either take a Vitagene DNA test or upload raw DNA data from either 23andMe, MyHeritage, or AncestryDNA. Vitagene does not accept raw DNA files from other companies. To generate its reports, VItagene compares customer DNA to a 50,000+ item database of research on genomics, nutrition, and exercise. 

The reports are organized into tiers, allowing customers to customize the information they receive. The three highest tiered products include access to an online coach. Although the company advertises health reports and recommendations, they are not a diagnostic company. They only report predispositions to certain traits based on the customer’s genetics.  

Reporting
  • Health + Ancestry Report
    • Diet
    • Supplement
    • Exercise
    • Ancestry
  • Premium Report
    • Diet
    • Supplement
    • Exercise
    • Ancestry
    • + Skin
  • Vitality Bundle
    • Diet
    • Supplement
    • Exercise
    • Ancestry
    • + 90-day supply of four customized supplements
    • + research updates
Cost
  • Health Report (raw DNA upload) – $49
  • Health and Ancestry Report – $99
  • Premium Report – $139
  • Vitality Bundle – $289
  • Vigor Bundle (raw DNA upload) – $169
Vitagene testing kit

GenoPalate 

Summary

GenoPalate is a DNA testing company that uses genetic testing to provide nutrition information and personalized diet recommendations. Customers can either upload raw DNA data from 23andMe or AncestryDNA or order a GenoPalate DNA kit to have their genes analyzed. Customers cannot upload raw DNA from other sources, such as Nebula Genomics. Testing kits are analyzed at third party labs and DNA results from these tests usually take 4-6 weeks. 

GenoPalate only analyzes genes related to nutrition. While customers can upload data from other sites, they cannot download raw data produced by the GenoPalate DNA test. Reviews for the service are mainly mixed with the largest criticism from customers being that the DNA results are too general. 

Reporting
  • Optimal intake for 23 nutrients, including amounts of vitamins and minerals
  • The 85 best foods to build a meal plan for personalized nutrition needs
  • Food sensitivities to lactose, gluten, alcohol, and caffeine
Cost
  • Report only (23andMe or Ancestry upload) – $69
  • DNA testing kit + report – $189
Genopalate testing kit

Best DNA test kit for Learning about disease risks and enhancing your health

  1. Nebula Genomics
  2. Helix DNA
  3. Veritas Genetics

Others: Sequencing.com, 23andMe, AncestryDNA, MyHeritage, SelfDecode, Dante Labs, WeGene, tellmeGen, CircleDNA

Nebula Genomics

Summary

Nebula Genomics uses comprehensive 30X Whole Genome Sequencing to decode 100% of your DNA and produce 10,000 times more data than other DNA tests like 23andMe and AncestryDNA, meaning that customers have even greater access to information on disease risks and pathways towards enhancing their health. 

Because personal genome sequencing enables the discovery of all genetic variation in every individual gene, it produces the most comprehensive and accurate genetic test results. Other tests only cover single gene sequencing, which can miss important health information. Whole genome sequencing is the best DNA test for discovering genetic health risks.

Nebula Genomics Whole Genome Sequencing is intended for educational and informational purposes only. However, since all DNA is sequenced in CLIA-approved and CAP-accredited laboratories, Nebula Genomics results can be brought and analyzed by any clinician or genetic counselor. These DNA results will provide the best insight into various clinical analyses including carrier screening, evaluation of disease risks, and rare disease diagnosis.

Reporting
  • Traits
  • Ancestry
  • Oral microbiome
  • Nebula Research Library (subscription): Personalized weekly reporting updates with polygenic scores to help customers interpret results and new traits added weekly
    • Genome exploration tools: user-driven data exploration 
      • Gene analysis tool – explore any gene of interest
      • Variant search tool – explore genetic variants reported in literature
      • Genome browser – direct look at sequencing data
Cost
  • DNA uploads from AncestryDNA and 23andMe DNA kits – free
  • 30X Whole Genome Sequencing – $0 – $299
  • Nebula Explore – $19.99 per month (monthly), $9.99 per month (yearly), or $700 (unlimited lifetime access)
Nebula Genomics logo

Helix DNA

Summary

Helix DNA offers both DNA testing kits and a variety of apps that analyze different parts of the DNA. The company provides health DNA testing in collaboration with Mayo Clinic, a top ranking medical center. Helix DNA testing is whole exome sequencing, which sequences some non-coding areas of DNA and mitochondrial DNA. Mutations that cause diseases are mostly found in the exome, the part of the human genome that codes for proteins.

In order to purchase a Helix DNA test, customers must complete a health questionnaire and a clinician will order the test. Overall, the cost is affordable for whole exome sequencing (as low as $145 for DNA testing and a single analysis). Additional reports in the form of apps can be purchased at a reduced price. It is noted that genealogy via the MyTraits Ancestry app provides limited genealogy reporting. Additionally, Helix has pivoted away from direct-to-consumer genetic testing. Therefore, future support for its products and DNA testing services appears uncertain.

Reporting

Based on app selection

Cost 
  • Mayo Clinic Gene Guide – $199
  • GenePrism Actionable Insights – $299
  • CarrierCheck – $250
  • Prostate Cancer Genetic Risk Score – $199
  • My Traits Sport – $145
  • GoalGetter – $190
  • Diet GENius – $145
  • Heart Start – $239
  • Helix ancestry – free (only available for users who have been sequenced by Helix)
  • Women’s Wellness – free (only available for users who have been sequenced by Helix)
  • Helix Wellness – free (only available for users who have been sequenced by Helix)
  • Genetic Counseling – $75
Helix DNA platform

Veritas Genetics

Summary

Veritas Genetics was the first genetic testing company to offer personal whole genome sequencing for less than $1000. Whole genome sequencing decodes almost 100% of the genome, while other tests only cover less than 1%. The Veritas Genetics reports focus on health information and disease risks. 

myGenome is the Veritas Genetics flagship product. The DNA test requires doctor authorization and a results consultation to help provide actionable insights into how DNA affects personal health. If a customer is unable to order through their own physician, Veritas Genetics partners with third-party physicians that will order the test for a fee. Along with the report, Veritas Genetics provides a 15-20 minute consultation with a genetic counselor. Raw DNA data can only be accessed with an additional fee of $99.

In their reports, customers can choose from three interpretation services. Standard provides customers with information on drug sensitivities, over 40 carrier conditions, and over 200 genetic diseases. Premium also includes more information on cancer, cardiovascular risks, and carrier conditions. It includes over 650 genetic conditions and over 225 carrier conditions. Finally, diagnostic is suited for customers with a complex medical history who are interested in how genetic information relates to their conditions. 

Reporting
  • 8 category clinical section 
    • Cancer susceptibility
    • Cardiovascular diseases
    • Clotting disorders
    • Endocrine and metabolic disorders
    • Immune disorders
    • Mitochondrial conditions & inheritance
    • Neurological disorders
    • Organ health
  • Results in the clinical section classified according to their potential health impact
    • Very important
    • Important
    • Noteworthy
  • Carriers
  • Pharmacogenomics

11 category trait section (>50 traits)

  • Athleticism 
  • Behavior
  • Cardiovascular
  • Hormones
  • Immune system
  • Longevity
  • Metabolis
  • Nutrition and diet
  • Physical appearance
  • Sensory perception
  • Substance reaction
  • Ancestry
Cost
  • Standard (Whole Genome Sequencing): $599 
  • Premium: $1,599
  • Diagnostic: $2,599 – $3,599
  • Access to raw DNA data: $99
  • Additional genetic counseling: $299 per hour
Veritas information

Best DNA test kit for Participating in research and contributing to new discoveries

  1. Nebula Genomics
  2. 23andMe
  3. Sano Genetics

Others: LunaDNA

Nebula Genomics

Summary

Nebula Genomics uses comprehensive 30X Whole Genome Sequencing to decode 100% of your DNA and produce 10,000 times more data than other DNA tests like 23andMe and AncestryDNA, meaning that customers have even greater access to information. Nebula Genomics partners with pharma and biotech companies to enable patient-centric genetic studies. They incentivize data sharing by ensuring equitable compensation, transparency, and security. Their mission is to help researchers and patients benefit from genetic information.

Study participants receive their raw genetic data and a report at no cost and the study sponsor receives access to genetic data and can use it for research purposes. Nebula takes care of the groundwork. The company recruits patients from their community and a network of advocacy to match research studies with patients meeting eligibility criteria. They also collect consents via IRB approvals and sequence DNA samples. Interested? Customers can read this case study highlighting the collaboration between Nebula Genomics and EMD Serono’s Lung study. 

Reporting

Patients get full access to their genomic data.

Cost

Patients/Consumers – free. Collaborations with pharma and biotech companies will sponsor sequencing in exchange for access to genomic data.

Nebula Genomics testing kit

23andMe

Summary

23andMe (23 and Me) made headlines as one of the first direct-to-consumer DNA testing companies to give customers access to their genetic information without professional medical consultation. Like AncestryDNA, it remains one of the most popular direct-to-consumer DNA tests. As of this reporting, 23 and Me has over 10 million users and the second largest user database for ancestry exploration. 

To analyze DNA tests, 23 and Me relies on Y-DNA (Y Chromosome), mtDNA (mitochondrial DNA), and autosomal DNA testing. While AncestryDNA focuses on family matches, 23 and Me hosts less information on historical records but includes trait analysis in their basic package.  

23 and Me sells three DNA tests, all including ancestry analysis:

  • Ancestry + traits
  • Health + ancestry
  • VIP health + ancestry

The trait analysis provides customers with information as to how non-medial genetic characteristics, like eye color and taste preference, originate. The health versions of the 23 and Me DNA test also include health reports that use a customer’s DNA to determine risk of genetic diseases. 

Reporting
  • Ancestry composition
  • Ancestry origin based on male and female haplogroups 
  • Neanderthal ancestry
  • DNA relative finder
  • Traits
  • Health predispositions (Health only)
  • Wellness (Health only)
  • Carrier status (Health only)
Cost
  • Ancestry + traits – $99
  • Health + ancestry – $199
  • VIP health + ancestry – $499
23andMe ancestry testing kit

Sano Genetics

Summary

Sano Genetics is a data-sharing platform aiming to connect patients and consumers with research projects. Participants can upload their DNA data and then choose to take part in different research studies. In return, participants receive access to personalized reports in their chosen research studies. In some cases, study participants can also be paid. Registration for the platform is free. 

Users can either upload raw DNA data from another genetic testing company like 23andMe, Ancestry, FamilyTreeDNA, and others or get their DNA analyzed with one of Sano Genetics DNA testing kits. Based on the provided information, Sano Genetics matches users with research projects that could benefit from their information. 

Sano Genetics offers three DNA testing kits that differ by how much of the genome they analyze: Genotyping, Exome Plus, or Whole Genome DNA sequencing. There is a fee for each of these tests although some research studies will pay for user tests. The company only produces small batches of these kits and thus they are not widely available.

Reporting
  • Public access to a collection of articles on genetically-determined traits

15 personalized trait reports based on their supported research to users who uploaded their genetic data or purchased a test

  • Circadian rhythms
  • Male pattern baldness
  • Nutrigenomics
  • Freckles
  • Eye color
  • Odor detection
  • Coffee and caffeine consumption
  • Nicotine dependence
  • Stress
  • Alcohol
  • Pain sensitivity
  • Taste preference
  • Eczema
  • Psoriasis
  • Food allergies
Cost
  • Upload raw DNA data – free
  • Genotyping DNA test – $150*
  • Exome Plus – $550*
  • Whole genome sequencing – $1200*

*Produced in small batches and not widely available.

Sano Genetics testing kit

Best DNA test kit for clinical disease diagnostic and prediction of drug side effects

  1. Invitae
  2. Color Genomics
  3. Ambry Genetics

Others: Myriad, GeneDx, GeneSight

Unlike these clinical genetic testing companies, Nebula Genomics is not diagnostic reporting. However, it is the best data you can bring to a genetic counselor or physician. 

Invitae

Summary

Invitae is a medical genetics company. The company sells a wide array of diagnostic tests for cancer, heart disease, reproductive health, and rare disorders. These tests can be ordered either by a patient or by a clinician on a patient’s behalf. Invitae also offers medical professionals access to special tools, such as the Invitae family history tool, which clinicians can use to digitally record patient family history to help recommend genetic testing. To date, the company has provided genetic testing to more than half a million individuals. 

Invitae uses two types of assays to analyze consumer DNA: Full-gene sequencing, which investigates clinically important regions of the genome, and exome analysis, which captures all coding gene variants. The largest limitation of their analysis is that they do not analyze non-coding regions of the genome, which are often associated with increased risks of certain health disorders. Invitae offers genetic counseling with all of its products and accepts insurance from most health plans, at least in part.

Reporting

Diagnostic tests

These tests can be ordered by either the patient or a medical provider

  • Hereditary cancer
  • Heart disease
  • Neurological conditions
  • Rare diseases
  • Pediatric conditions

These categories of diagnostic tests can only be ordered by medical providers

  • Cardiology
  • Dermatology
  • Exome
  • Hematology
  • Hereditary cancer
  • Immunology
  • Metabolic disorders and newborn screening
  • Nephrology
  • Neurology
  • Ophthalmology
  • Pediatric genetics

Proactive tests

These tests cannot be covered by insurance

  • Cancer screen
  • Cardo screen
  • Genetic health screen

Reproductive tests

Except for the carrier screening, these tests must be purchased by a medical provider

  • Carrier screening
  • Non-invasive prenatal screening (NIPS)
  • Prenatal diagnostic testing
  • Preimplantation genetic testing (PGT)
  • Pregnancy loss
Cost

Most Invitae tests may be covered entirely by insurance. In certain instances, insurance may only cover a portion of the cost and customers may receive a bill. Proactive tests are not covered by insurance:

  • Cancer screen – $250
  • Cardio screen – $250
  • Genetic health screen – $350
  • Carrier screening – $250
Invitae testing kit

Color Genomics

Summary

Color Genomics is a clinical genetic testing company. A physician, either the customer’s personal doctor or one assigned by Color Genomics, must order the test. Both the customer and the ordering physician receive a copy of the DNA results, which assess whether the customer has certain genetic mutations that put them at risk for a genetic disease. Results from Color DNA tests do not diagnose diseases, but just report predispositions. 

Color genomics offers two publically available DNA tests: Color Genomics Extended, which analyzes 74 genes related to cancer and heart health and Color Genomics Hereditary Cancer, which focuses solely on cancer genetics. Like Color Genomics, Nebula Genomics is not a diagnostic company. However, Nebula’s whole genome sequencing provides the most comprehensive genetic data that can also be brought to a genetic counselor or physician. 

Reporting
  • DNA health report that analyzes up to 74 genes in 3 categories (cancer, heart disease, medication)
  • The presence of risk-increasing mutations
  • How risk-increasing mutations might impact family members
  • Risk information and cancer screening guidelines 
Cost
  • Extended: $249
  • Hereditary Cancer: $249
Color Genomics testing kit

Ambry Genetics

Summary

Ambry provides genetic testing services for hereditary cancer, cardiac disease, neurological disease, and many other diseases using targeted sequencing methods. Unlike consumer genetics-focused companies such as 23andMe and AncestryDNA, Ambry Genetics does not sell its DNA test kits directly to consumers. All products must be purchased by a clinician and they do not provide access to raw DNA data.

The customer’s healthcare provider will consult with the patient and determine the appropriate testing kit. Once the kit is ordered, the patient will take the test and the DNA results are sent directly to the ordering physician, who will then discuss the test results with the patient. 

Depending on the type of information desired, Ambry will perform either a SNP array (detects specific genetic variants), targeted gene sequencing (next generation sequencing that focuses on genes related to specific disease), or whole exome testing (sequences 20,000 genes – 98% non-coding, 2% of entire genome).

Ambry Genetics provides post test genetic counseling for cancer patients that receive results indicating the presence of a clinically significant mutation. 

Reporting*
  • Results – presence of clinically significant mutations
  • Summary – whether the test was positive/negative/unknown
  • Interpretation – detailed analysis, including risk analysis and genetic counseling recommendations
  • Assay information – how the genetic test was performed

*The DNA test reports are tailored for genetic counselors with relevant supplementary materials for patients depending on the results.

Cost
  • Covered entirely by insurance – as low as $0
  • With financial aid – as low as $100
  • Without insurance or financial aid – $3,290 (reported by customer on Reddit testimonial)
Ambry Genetics logo

Best DNA app stores and marketplaces

  1. Sequencing.com
  2. GenePlaza
  3. Helix

Sequencing.com

Summary

Customers can upload raw DNA from 23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage, or Gencove and receive extended reports on their genome. Sequencing.com offers two different tests if customers do not have DNA data. The first test is DNA testing for ancestry information while the second is whole genome sequencing, which gives customers the most comprehensive view of their genome and how their genes affect health and wellness. 

Sequencing.com is most well known for their DNA app store. Some apps are free while others cost as much as $399 for in-depth DNA analysis. Customers can purchase subscriptions to receive free apps. Most apps generate a report analyzing specific characteristics such as ancestry, fitness, beauty, and even things like art. As of 2020, Sequencing.com has the largest DNA app marketplace with over 100 different apps that cover various aspects of the human genome. 

Some apps are helpful for groups of people with specific fitness goals, like the Athletic Training Pro app which analyzes genetically influenced aspects of fitness. Others are just for fun like the Santa and Me app which compares your DNA with Santa’s genetic makeup. 

Reporting
  • Over 100 apps in the DNA app store that provide ancestry, health and other types of reporting
Cost 
  • The Ultimate DNA Test: $69
  • Whole Genome Sequencing: $399
  • Apps: $0 – $399
    • Silver membership (2 free apps per month): $9.99 per month
    • Gold membership (4 free apps per month): $29.99 per month 
    • Platinum membership (6 free apps per month + genetic counseling): $49.99 per month
Sequencing.com testing kit

GenePlaza

Summary

GenePlaza offers 17 individual apps to analyze DNA data as well as a DNA testing kit. According to GenePlaza founder, Alain Coletta, GenePlaza is the first company that allows users to purchase apps for DNA analysis. Each app tends to focus on one trait, allowing customers a targeted approach to genetic research. However, this approach necessitates that customers purchase multiple products for a more complete view of their DNA. 

The apps are designed by researchers, providing the platform a certain level of credibility. Each app cites the research the results are based on. Once users create an account, they can upload raw DNA data from 23andMe or AncestryDNA. Customers in Europe can purchase a DNA testing kit if they do not have raw data. The GenePlaza DNA test genotypes 700,000 specific locations on the genome. At €164 (~$180 USD), this test is more expensive than alternatives.

Reporting
  • SAPDA: Infers your ancestry
  • The K35 Calculator: Genetic similarity to ancient reference populations from the Bronze and Iron ages
  • Bronze Age DNA Test – Advance: a high-resolution DNA test, which calculates the proportion of 10 ancient gene pools
  • Bronze Age DNA Test – Beginner: a low-resolution DNA test, which calculates the proportion of 6 ancient gene pools
  • The K29 Admixture Calculator: Genetic similarity to various populations around the world
  • The K5 Admixture: Measures relatedness of individuals to highly diverged populations of Eurasia, including West, South, East Eurasians, and Native Americans
  • Addictions: Predicts drug addiction related genetic variants
  • Math Ability: Relative math ability compared to the rest of the population
  • Depression App: Genetic predisposition to having depression
  • Sleep Zzz: Predisposition to being an early bird or night owl
  • Ci-lantro vs No-lantro: Likelihood of you finding the taste of cilantro similar to soap
  • Coffee Metabolism: How quickly you can metabolize coffee
  • Intelligence App: Uses a genetic model from a study that measured intelligence. For each user, the app predicts their intelligence score if they had participated in the study
  • Health Traits: Predisposition to certain diagnoses and psychological factors like needing glasses or mood swings
  • Ethnicity Calculator: Visualizes your ethnic distance to different populations
  • Ancestry: Estimates the locations & regions where your ancestors may have lived
  • My Weight: Genetic predisposition to be overweight
  • Taste Perception: Whether you would be “bitterness-blind” or a “super-taster” 
  • Neuroticism App: Tendency to be neurotic  
  • 122 Shades of Gray: (Discontinued) Predicted predisposition to same-sex attraction.
  • Sano Genetics – contribute to research: Matches users to potential research studies that they can participate in by sharing their genetic information 

The app page of GenePlaza website indicates that there are many more apps to come.

Cost
  • DNA testing kit (Europe only): $164
  • Raw DNA upload: Free
  • Apps (available worldwide): $1.61 – $48, most are under $5
  • SAPDA – $13.65
  • The K35 Calculator – $6
  • Bronze Age DNA Test – Advance – $48
  • Bronze Age DNA Test – Beginner – $30
  • The K29 Admixture Calculator – $5
  • The K5 Admixture – $9
  • Addictions – $5.50
  • Math Ability – $4
  • Depression App – $3.50
  • Sleep Zzz – $2.49
  • Ci-lantro vs No-lantro – $1.49
  • Coffee Metabolism – $1.49
  • Intelligence App – $6
  • Health Traits – $5.49
  • Ethnicity Calculator – $4.49
  • My Weight – $2.49
  • Taste Perception – $1.49
  • 122 Shades of Gray – (Discontinued) 
GenePlaza app example

Helix DNA

Summary

Helix DNA offers both DNA testing kits and a variety of apps that analyze different parts of the DNA. Customers can sequence their DNA once and explore individual genetic aspects such as ancestry and heart health through different apps. Their DNA testing is whole exome sequencing, which sequences some non-coding areas of DNA and mitochondrial DNA. This approach is important since genetic mutations that cause diseases are mostly found in the exome, the part of the human genome that codes for proteins.

In order to purchase a Helix DNA test, customers must complete a health questionnaire and a clinician will order the test. Overall, the cost is affordable for whole exome sequencing (as low as $145 for DNA testing and a single app). Additional apps can be purchased at a reduced price. It is noted that genealogy via the MyTraits Ancestry app only provides limited genealogy reporting. 

Reporting

Based on app selection

Cost 
  • Mayo Clinic Gene Guide – $199
  • GenePrism Actionable Insights – $299
  • CarrierCheck – $250
  • Prostate Cancer Genetic Risk Score – $199
  • My Traits Sport – $145
  • GoalGetter – $190
  • Diet GENius – $145
  • Heart Start – $239
  • Helix ancestry – free (only available for users who have been sequenced by Helix)
  • Women’s Wellness – free (only available for users who have been sequenced by Helix)
  • Helix Wellness – free (only available for users who have been sequenced by Helix)
  • Genetic Counseling – $75
Helix DNA platform

Best DNA test kit for Whole Genome Sequencing

  1. Nebula Genomics
  2. Sequencing.com
  3. Veritas Genetics

Others: Sano Genetics, Dante Labs, Full Genomes, YSeq

Nebula Genomics

Summary

Nebula Genomics uses comprehensive 30X Whole Genome Sequencing to decode 100% of your DNA and produce 10,000 times more data than other DNA tests like 23andMe and AncestryDNA, meaning that customers have even greater access to information. This personal sequencing technique provides customers the most comprehensive and accurate test results. Other DNA tests only decode less than 1% of DNA. 

Nebula Genomics offers the most affordable whole genome sequencing. For between $0 – $299, customers can unlock their entire genome sequence. Users upload, expand, and receive reports for their DNA for free by uploading raw DNA data from 23andMe or AncestryDNA. Expansion takes partial DNA data and expands it more than 50 times to over 35 million genetic variants. If they don’t have DNA data, customers can get their whole genome sequenced for less than $300. 

Reporting
  • Nebula Research Library – new reports every week based on latest research studies
  • Genome Exploration Tools – dynamic tools to ask questions about DNA
  • Deep Genetic Ancestry – full Y chromosome and mitochondrial DNA sequencing and analysis
Cost
  • DNA uploads from AncestryDNA and 23andMe DNA kits – free
  • 30X Whole Genome Sequencing – $0 – $299
  • Nebula Explore – $19.99 per month (monthly), $9.99 per month (yearly), or $700 (unlimited lifetime access)
Nebula Genomics testing kit

Sequencing.com

Summary

Customers can upload raw DNA from sites like 23andMe and AncestryDNA and receive extended reports on their genome. Sequencing.com also offers two different testing processes if customers do not have DNA data. The first test is DNA testing for ancestry information while the second is whole genome sequencing. Whole genome sequencing decodes almost 100% of the genome, while other tests only cover less than 1%. This service gives customers the most comprehensive view of their genome and how their genes affect health and wellness. 

Sequencing.com is most well known for their DNA app store. Most apps generate a report analyzing specific characteristics such as ancestry, fitness, beauty, and even things like art. As of 2020, Sequencing.com has the largest DNA app marketplace with over 100 different apps that cover various aspects of the human genome. 

Reporting
  • Over 100 apps in the DNA app store that provide ancestry, health and other types of reporting
Cost 
  • The Ultimate DNA Test: $69
  • Whole Genome Sequencing: $399
  • Apps: $0 – $399
    • Silver membership (2 free apps per month): $9.99 per month
    • Gold membership (4 free apps per month): $29.99 per month 
    • Platinum membership (6 free apps per month + genetic counseling): $49.99 per month
Sequencing.com testing kit

Veritas Genetics

Summary

Veritas Genetics was the first genetic testing company to offer personal whole genome sequencing for less than $1000. Whole genome sequencing decodes almost 100% of the genome, while other tests only cover less than 1%. The Veritas Genetics reports focus on health information and disease risks. 

myGenome is the Veritas Genetics flagship product. The DNA test requires doctor authorization and results consultation to help provide actionable insights into how DNA affects personal health. If a customer is unable to order through their own physician, Veritas Genetics partners with third-party physicians that will order the test for a fee. Along with the report, Veritas Genetics provides a 15-20 minute consultation with a genetic counselor. Raw DNA data can only be accessed with an additional fee of $99.

In their reports, customers can choose from three interpretation services. Standard provides customers with information on drug sensitivities, over 40 carrier conditions, and over 200 genetic diseases. Premium also includes more information on cancer, cardiovascular risks, and carrier conditions. It includes over 650 genetic conditions and over 225 carrier conditions. Finally, diagnostic is suited for customers with a complex medical history who are interested in how genetic information relates to their conditions. 

Reporting
  • 8 category clinical section 
    • Cancer susceptibility
    • Cardiovascular diseases
    • Clotting disorders
    • Endocrine and metabolic disorders
    • Immune disorders
    • Mitochondrial conditions & inheritance
    • Neurological disorders
    • Organ health
  • Results in the clinical section classified according to their potential health impact
    • Very important
    • Important
    • Noteworthy
  • Carriers
  • Pharmacogenomics

11 category trait section (>50 traits)

  • Athleticism 
  • Behavior
  • Cardiovascular
  • Hormones
  • Immune system
  • Longevity
  • Metabolis
  • Nutrition and diet
  • Physical appearance
  • Sensory perception
  • Substance reaction
  • Ancestry
Cost
  • Standard (whole genome sequencing) – $599 
  • Premium – $1,599
  • Diagnostic – $2,599 – $3,599
  • Access to raw DNA data – $99
  • Access to raw DNA data – $99
Veritas information

Best DNA test kit for paternity testing

  1. HomeDNA

HomeDNA

Summary

HomeDNA is one of the best paternity DNA test kits. It is owned by the DNA Diagnostics Center (DDC), a paternity and forensic DNA testing company founded in 1995. Previously known as IDENTIGENE, HomeDNA paternity test kits use cheek swabs as sources of DNA to analyze 15-17 different genetic regions from DNA samples collected from the biological mother, child, and potential father to determine paternity. After the samples arrive at the lab, the paternity results are available in just two business days. 

In 2017, HomeDNA became the first company to offer at-home DNA testing kits in stores across the country like Walgreens and CVS. These products include additional DNA tests such as HomeDNA Starter Ancestry, HomeDNA Food and Pet Sensitivity, HomeDNA Healthy Weight, and HomeDNA Skin Care. In most states, HomeDNA testing kits cannot be used as admission in court to determine legal paternity or in cases of child support. Only in New York state does this at home DNA collection and analysis meet the requirements for legal testing.

Reporting
  • Determination of paternity when DNA samples from the mother, child, and potential father are submitted
Cost
  • HomeDNA Paternity test – $28.99 for the DNA testing kit plus $139 lab fee
  • Ancestry tests – $69 – $124
  • Health and beauty tests – $139 – $159
HomeDNA testing kit

Best DNA upload sites

Best free DNA data upload sites for ancestry analysis

  1. GEDmatch Genesis
  2. FamilyTreeDNA
  3. MyTrueAncestry

Others: DNA land, MyHeritage, LivingDNA, DNA Painter

GEDmatch Genesis

Summary

GEDmatch Genesis is a DNA upload site that caters to amatuer and professional geniologists. Customers can upload DNA from various DNA testing sites and use GEDmatch Genesis’s databases to match DNA with relatives among the site’s 1.3 million users. In 2018, GEDmatch Genesis gained national fame when it was used by law enforcement to capture the infamous Golden State Killer. 

Users can upload either raw DNA from sites like 23andMe and AncestryDNA or family tree data in GEDCOM file for free. Ancestry test results are available in minutes but the main family finder tool takes several days to run. This tool mostly provides access to relative finding, without any other features. For first time users, the tool can appear complex. 

Reporting
  • One to many “GEDMatch Genesis System”. This tool searches the database to see which parts of the user’s DNA matches samples in the GEDmatch database. 
    • Kit number
    • Alias
    • Email address
    • Largest segment
    • Total cM
    • Generations
    • Overlap
    • Date compared
    • Testing company
Cost
  • DNA upload – free
  • DNA analysis tools (3,000 matched DNA kits) – free
  • Tier 1 features (10,000 matched DNA kits) – $10 per month
GEDmatch Genesis logo

FamilyTreeDNA

Summary

FamilyTreeDNA is a genetic genealogy company founded in 2000. They provide a DNA matching database for autosomal DNA, Y-DNA and mtDNA. WIth over 2 million users, FamilyTreeDNA’s database is one of the most comprehensive databases. 

Users can upload AncestryDNA, 23andMe, or MyHeritage data for free. It should be noted that uploading autosomal DNA data from these sources will only provide basic ancestry information. FamilyTreeDNA has also partnered with Nebula Genomics to offer the most comprehensive view of ancestry using Nebula’s whole genome sequencing that decodes 100% of the customer genome. This partnership gives customers access to deep ancestry databases for Y-DNA and mtDNA provided by FamilyTreeDNA. 

Reporting
  • Explore heritage on maternal and paternal lines
  • Connect with paternal or maternal-line relatives the databases
  • Follow the migration paths of your male or female ancestors
  • Trace your paternal surname to its roots and build your family tree (paternal ancestry)
  • Personalized mtDNA Full Sequence video (maternal ancestry)
  • Percentage breakdown of origins (Family ancestry)
  • Connect with autosomal DNA relatives within the last 5 generations (Family ancestry)
  • Connections with ancient European groups (Family ancestry)
  • Compare matching segments of DNA with genetic matches (Family ancestry)
Cost
  • Raw DNA upload using AncestryDNA, 23andMe, or MyHeritage data – free
  • Y-DNA paternal ancestry – $199 – $449 (price based on coverage amount)
  • mtDNA maternal ancestry – $159
  • Family Finder family ancestry – $70
FamilyTreeDNA example

MyTrueAncestry

Summary

MyTrueAncestry (My True Ancestry) uses raw DNA data from sites like Nebula Genomics, 23andMe, and AncestryDNA to assess genetic links between customer DNA, historical figures, and ancient civilizations. MyTrueAncestry does not sell their own DNA testing kits. Unlike most popular DNA testing sites that use population samples, MyTrueAncestry creates databases mainly from archeological sites. This method makes it easier to connect modern humans to ancient civilizations, but it also limits the accuracy of the results since only a single sample may be used. The company claims connections to ancient Europe date as far back as 550 AD.

Reporting
  • Closest ancient populations (e.g., Byzantine, Franks, Greek)
  • Modern populations (e.g., Norwegian, Ashkenazi Jewish)
  • Indigenous American matches for Native American ancestry
  • A breakdown of ancient ancestral matches by era (e.g. Bronze age and Dark ages)
  • MyTrueAncestry haplogroup analytics
  • “Outliers,” indicating which populations a user matches with most uniquely
Cost
  • Commoner: Free basic analysis: 10 of your 20 closest ancient samples. 2D visualization samples. Expires after 48 hours
  • Footman: $37: 20 total ancient sample matches. 3D visualization charts. Results do not expire
  • Knight: $55: 40 ancient samples:  “Premium Maps,” which suggest migration paths, and “Partial Deep Dive” results. 1 additional genome file upload
  • King: $100: 60 ancient DNA samples. 5 genome files. Deep Dive Maps and Analyses are complete at this tier. Users can also access more regional maps that span large time periods
  • Caesar: $149: 60 close-matched ancient samples. 10 genome files. MyTrueAncestry also provides Haplogroups (a group of people sharing a common ancestor) and more information about the DNA sample sources. They even reveal dig-sites
  • Zeus: $248: Users can make their own maps in real-time 
  • Olympus: $397: Users can customize genomic kits using data from ancient DNA samples
MyTruAncestry example

Best paid DNA data upload sites for ancestry analysis

  1. FamilyTreeDNA
  2. GEDmatch Genesis
  3. Living DNA

Others: YFull, MyTrueAncestry, DNA Land, MyHeritage, LivingDNA, WeGene

FamilyTreeDNA

Summary

FamilyTreeDNA is a genetic genealogy company founded in 2000. They provide a DNA matching database for autosomal DNA, Y-DNA and mtDNA. WIth over 2 million users, FamilyTreeDNA’s database is one of the most comprehensive databases. 

Users can upload AncestryDNA, 23andMe, or MyHeritage data for free. 

If they don’t have raw DNA data, customers can choose from three DNA testing products: Y-DNA paternal ancestry (male-specific test), mtDNA maternal ancestry (male and female test), or Family Finder family ancestry (male and female test). The paternal and maternal tests allow customers to trace migration patterns of their ancestors, connect with relatives, and build their family trees. The ancestry test provides a more refined view of family origins. 

Reporting
  • Explore heritage on paternal or maternal lines
  • Connect with paternal or maternal-line relatives the databases
  • Follow the migration paths of your male or female ancestors
  • Trace your paternal surname to its roots and build your family tree (paternal ancestry)
  • Personalized mtDNA Full Sequence video (maternal ancestry)
  • Percentage breakdown of origins (Family ancestry)
  • Connect with autosomal DNA relatives within the last 5 generations (Family ancestry)
  • Connections with ancient European groups (Family ancestry)
  • Compare matching segments of DNA with genetic matches (Family ancestry)
Cost
  • Y-DNA paternal ancestry – $199 – $449 (price based on coverage amount)
  • mtDNA maternal ancestry – $159
  • Family Finder family ancestry – $70
FamilyTreeDNA testing kit

GEDmatch Genesis

Summary

GEDmatch Genesis is a DNA upload site that caters to amatuer and professional geniologists. Customers can upload DNA from various DNA testing sites and use GEDmatch Genesis’s databases to match DNA with relatives among the site’s 1.3 million users. In 2018, GEDmatch Genesis gained national fame when it was used by law enforcement to capture the infamous Golden State Killer. 

Users can upload either raw DNA from sites like 23andMe and AncestryDNA or family tree data in GEDCOM file for free. Ancestry test results are available in minutes but the main family finder tool takes several days to run. This tool mostly provides access to relative finding, without any other features. For first time users, the tool may appear complex. 

Reporting
  • One to many “GEDMatch Genesis System”. This tool searches the database to see which parts of the user’s DNA matches samples in the GEDmatch database. 
    • Kit number
    • Alias
    • Email address
    • Largest segment
    • Total cM
    • Generations
    • Overlap
    • Date compared
    • Testing company
Cost
  • DNA upload – free
  • DNA analysis tools (3,000 matched DNA kits) – free
  • Tier 1 features (10,000 matched DNA kits) – $10 per month
GEDmatch Genesis logo

Living DNA

Summary

Living DNA is a genetics testing company that offers autosomal DNA tests. They provide health and fitness reports as well as ancestry reports for several regions worldwide. After registering for Living DNA, users can sign up to be part of research studies conducted by the company. The basic ancestry report includes information about ethnic origins in eight broader regions of Oceania, American continents, Africa, Europe, Near East, Central Asia, South Asia, and East Asia. In order to get more detailed analysis comparable to other DNA testing companies, customers must upgrade their plan. 

Living DNA provides free DNA upload. If customers choose to upload DNA for free, they will only have access to the basic results in the eight worldwide  locations. If they wish to purchase a DNA test, customers can choose from an ancestry starter kit, a full ancestry kit, or a well-being kit. 

Reporting
  • Ancestry tracing up to 10 generations
  • Ethnic estimates from over 150 subregions in the world, allowing for deep ancestry 
  • Separate maternal and paternal lineage results, including migration routes
  • Extended family network mapping
Cost

Additional shipping costs apply. For customers in the U.S., these can range from $49 to $99.

  • Raw DNA upload – free
  • Ancestry starter kit – $49
  • Full ancestry kit – $99
  • Well-being kit – $129
  • Well-being and DNA ancestry kit – $179
Living DNA testing kit

Best free DNA data upload sites for (health) trait analysis

  1. Nebula Genomics
  2. Genetic Genie
  3. Genomelink

Nebula Genomics

Summary

Nebula Genomics uses comprehensive 30X Whole Genome Sequencing to decode 100% of your DNA and produce 10,000 times more data than other DNA tests like 23andMe and AncestryDNA, meaning that customers have even greater access to information on disease risks and pathways towards enhancing their health. Customers can upload raw DNA data from 23andMe or AncestryDNA and free.

Because personal genome sequencing enables the discovery of all genetic variation in every individual gene, it produces the most comprehensive and accurate genetic test results. Other tests only cover single gene sequencing, which can miss important health information. Whole genome sequencing is the best DNA test for discovering genetic health risks and to use in consultation with physicians or genetic counselors. 

Nebula Genomics Whole Genome Sequencing is intended for educational and informational purposes only. However, since all DNA is sequenced in CLIA-approved and CAP-accredited laboratories, Nebula Genomics results can be analyzed by a clinician or genetic counselor. These results will provide the best insight into various clinical analyses including carrier screening, evaluation of disease risks, and rare disease diagnosis.

Traits included in a Nebula Genomics report are sorted into four categories of Appearance and Hormones, Behavior and Perception, Body and Athleticism, and Nutrition and Diet. Customers receive information on the name of the trait, which gene it is associated with, and which variant is being looked at for the trait. The report also includes a more in depth description on how the variant is expressed in the customer’s genome. 

Reporting
  • Traits
  • Ancestry
  • Oral microbiome
  • Nebula Research Library (subscription): Personalized weekly reporting updates with polygenic scores to help customers interpret results and new traits added weekly
    • Genome exploration tools: user-driven data exploration 
      • Gene analysis tool – explore any gene of interest
      • Variant search tool – explore genetic variants reported in literature
      • Genome browser – direct look at sequencing data
Cost
  • DNA uploads from AncestryDNA and 23andMe DNA kits – free
  • 30X Whole Genome Sequencing – $0 – $299
  • Nebula Explore – $19.99 per month (monthly), $9.99 per month (yearly), or $700 (unlimited lifetime access)
Nebula Genomics logo

Genetic Genie

Summary

Genetic Genie is a free DNA data analysis service created by a patient named Kyle who has a chronic illness and desires more access to connections between DNA and diseases. The reports are centered on health and wellness. Customers can obtain these free DNA health reports by uploading raw DNA data from Nebula Genomics, 23andMe, AncestryDNA, and other genome sequencing companies. 

Once they upload their raw DNA data, customers can access three DNA analysis and health report products: GenVue Discovery (genetic variants only), methylation cycle profile (chemical modifications on DNA), and detox profile (SNPs on detox enzymes). One of the downsides to all of these analyses is that sites like 23andMe and Ancestry only record a small part of the genome, possibly creating an incomplete analysis when imputed to Genetic Genie. 

Reporting
  • Detailed reports on disease risks based on genetic variants 
  • References to scientific publications and genetic databases
Cost
  • Free
Genetic Genie logo

Genomelink

Summary

Genomelink is a DNA data upload and analysis service. It supports uploads of 23andme, Ancestry, or MyHeritage data files. Users receive insights into nutrition, including foods you eat, personality traits, and fitness. Trait analysis includes Physical Traits (i.e. dog allergic reactions, freckles), Personality (i.e. empathy, fear of pain), Intelligence (i.e. music ability), Food & Nutrition (alcohol drinking behavior, Vitamin D), and Fitness (i.e. muscular strength). The company does not analyze health related genetics. 

Reports produced by Genomelink are clear and comprehensive and the first 25 trait analyses are free. If you have already obtained raw DNA data from one of the supported sites, there is little apparent risk in trying the Genomelink service. Some reviews indicate that the reports are more “fun” based rather than serious deep dives into health and ancestry. Additionally, there is disagreement among experts as to whether traits like intelligence can be accurately associated with genes. 

Reporting
  • Presence of genetic variants estimate a tendency to exhibit a specific trait. Traits are organized into 5 main categories: Food & Nutrition (28 traits), Personality (37 traits), Intelligence (14 traits), Fitness (11 traits), and Physical traits (43 traits)
  • Level of reliability
  • Research papers
Cost
  • Access to 25 traits – free
  • Access to 150+ traits – $14 per month 
  • Ancient Ancestry Report – $29
  • Personalized Nutrition Advice – $24
  • Personalized Fitness Report – $39
Genomelink logo

Paid DNA data upload sites for (health) trait analysis

  1. Nebula Genomics
  2. Promethease
  3. Genomelink

Others: Genopalate, FitnessGenes, Vitagene, SelfDecode, Xcode Life, GenePlaza, WeGene

Nebula Genomics

Summary

Nebula Genomics uses comprehensive 30X Whole Genome Sequencing to decode 100% of your DNA and produce 10,000 times more data than other DNA tests like 23andMe and AncestryDNA, meaning that customers have even greater access to information on disease risks and pathways towards enhancing their health. Customers can upload raw DNA data from 23andMe or AncestryDNA and free.

Other tests only cover single gene sequencing, which can miss important health information. Whole genome sequencing is the best DNA test for discovering genetic health risks. 

Nebula Genomics whole genome sequencing is for educational and informational purposes only. However, since DNA is sequenced in CLIA-approved and CAP-accredited laboratories, results can be analyzed by a clinician or genetic counselor. These results will provide the best insight into various clinical analyses including carrier screening, evaluation of disease risks, and rare disease diagnosis.

Nebula Explore subscribers receive access to personalized reports on new traits in the Nebula Research library. Customers will see a summary of each article along with the research article title, authors, publication date, and publication journal. Polygenic scores that summarize customer genetic variants and compare them to other Nebula Genomics users are also provided. New reports are added weekly. 

Reporting
  • Traits
  • Ancestry
  • Oral microbiome
  • Nebula Research Library (subscription): Personalized weekly reporting updates with polygenic scores to help customers interpret results and new traits added weekly
    • Genome exploration tools: user-driven data exploration 
      • Gene analysis tool – explore any gene of interest
      • Variant search tool – explore genetic variants reported in literature
      • Genome browser – direct look at sequencing data
Cost
  • DNA uploads from AncestryDNA and 23andMe DNA kits – free
  • 30X Whole Genome Sequencing – $0 – $299
  • Nebula Explore – $19.99 per month (monthly), $9.99 per month (yearly), or $700 (unlimited lifetime access)
Nebula Genomics logo

Promethease

Summary

Promethease is a website for genome health reporting. Promethease uses aggregated research studies in SNPedia’s library to provide users with information on their genetic variants. The SNPedia library contains health information on over 100,000 gene variants. Users can upload raw DNA data from Nebula Genomics, 23andMe, AncestryDNA, and other DNA tests. The flagship product is the DNA health report. Promethease does not offer DNA testing or ancestry analysis.

Prometheus reports can be customized by medical conditions. They can also be filtered by strength of evidence in the original research and searched by gene, body part, or condition.  In addition to the health analysis reports, customers can access the scientific studies on which their results are based. The reports are very detailed, but the platform can be unintuitive at times.  

Reporting
  • Detailed relationships between user’s genetic variants and health traits
  • Analyzes medical history and genetic health risks based on family history
Cost

$12 per report

Promethease logo

Genomelink

Summary

Genomelink is a DNA data upload and analysis service. It supports uploads of 23andme, Ancestry, or MyHeritage data files. Users receive insights into nutrition, including foods you eat, personality traits, and fitness. Such traits include Physical Traits (i.e. dog allergic reaction, freckles), Personality (i.e. empathy, fear of pain), Intelligence (i.e. music ability), Food & Nutrition (alcohol drinking behavior, Vitamin D), and Fitness (i.e. muscular strength). The company does not analyze health related genetics. 

Reports produced by Genomelink are clear and comprehensive and the first 25 trait analyses are free. If you have already obtained raw DNA data from one of the supported sites, there is little apparent risk in trying the Genomelink service. Some reviews indicate that the reports are more “fun” based rather than serious deep dives into health and ancestry. Additionally, there is disagreement among experts as to whether traits like intelligence can be accurately associated with genes. 

Reporting
  • Presence of genetic variants estimate a tendency to exhibit a specific trait. Traits are organized into 5 main categories: Food & Nutrition (28 traits), Personality (37 traits), Intelligence (14 traits), Fitness (11 traits), and Physical traits (43 traits)
  • Level of reliability
  • Research papers
Cost
  • Access to 25 traits – free
  • Access to 150+ traits – $14 per month 
  • Ancient Ancestry Report – $29
  • Personalized Nutrition Advice – $24
  • Personalized Fitness Report – $39
Genomelink logo

Best lab test

  1. EverlyWell
  2. LetsGetChecked
  3. MyLab Box

EverlyWell

Summary

Everlywell (Everly Well) is an at-home testing company that became famous in 2017 when CEO Julia Cheek brought the product to ABC’s Shark Tank. Everlywell uses biomarkers to analyze particular health conditions without having to perform a blood draw at a doctor’s office. Although some of their products are skin prick tests.

Everlywell does not use genetic biomarkers in their tests. However, in 2017, Everlywell partnered with Helix to offer genetic testing in addition to the biomarker testing. 

Some of the company’s most popular tests are Everlywell’s food sensitivity test, which tests for food sensitivities in over 96 foods specific and common to a western diet. Reports include information on how test results may affect a customer’s health. The test works through Immunoglobulin G (IGg) testing in which the company analyzes for immunoglobulin IgG antibodies in response to certain foods. The difference between allergy and intolerance should be noted. IgG only relates to food sensitivities. Immunoglobulin E (IgE) antibodies would be needed to test for food allergies. 

Results may be used as guidance for customers to use in consultation with their doctors to confirm food intolerance. Physicians may recommend an elimination diet to confirm Everylywell results.

Reporting
  • Quantitatively measurements of specific biomarkers that are associated with health conditions
  • How the test results may affect health
  • Insights on how to improve or maintain healthy biomarker levels
  • Links to related medical research
Cost
  • General wellness tests: $49 – $259
  • Men’s health tests: $59 – $179
  • Women’s health tests: $79 – $399
  • Energy + Weight tests: $79 – $159
  • Sexual health tests: $49 – $199 
Everlywell Food Sensitivity Test

LetsGetChecked

Summary 

LetsGetChecked is an at home medical testing service. Customers can access tests for fertility, sexual health, cancer screening (including a colon cancer screening test), hormone, and “lifestyle”. This option is particularly attractive for customers who aren’t able to visit a doctor’s office or would prefer to take these tests from the privacy of their own home. 

LetsGetChecked offers 34 at-home testing products that send collection kits for blood tests, urine, vaginal swab, nasal swab, or stool samples to test for certain health conditions. Most tests are sold individually but others can be purchased as a combination, like the 5 standard STD test. Results can be accessed by the patient discreetly over a secure online platform.

Reporting
  • Detection tests (STDs, others) – Positive or negative result, with context
  • Result range tests (vitamin test, hormones, etc.) – Biomarker test measurements, compared with normal values
Cost
  • General wellness (17 tests) – $49 – $199
  • Women’s health (4 tests) – $89 – $139
  • Men’s health (5 tests) – $69 – $179
  • Sexual health (2 tests, 2 coming soon) – $79-$119
  • Sexual health bundles (9 tests, 4 different bundles) – $99 – $349
LetsGetChecked testing kit

MyLab Box

Summary

MyLab Box is the longest-running nationwide service that provides testing at home for sexually transmitted diseases (STDs). The company’s initial mission was to give customers peace of mind by making STD testing easier, more affordable, and accessible to customers in their own homes. 

MyLab Box ultimately offers four categories of health care testing kits (STDs, wellness & nutrition, drug tests, and fertility). Depending on the type of test, customers provide either a nasal swab, urine sample, vaginal swab, or blood sample via finger prick. If a test is positive, customers can receive a free phone consultation with a MyLab Box physician affiliate. In some cases, treatments such as antibiotics can be sent to a customer’s pharmacy. Availability of consultation and treatment options vary by state. The company claims that results are comparable to those obtained at a doctor’s office or clinical laboratory. 

Reporting
  • Presence of STDs and other health conditions
Cost
  • STD individual tests (11 tests) – $79 – $179
  • STD box bundles (6 bundles) – $189 – $399
  • General health (7 tests) – $59 – $199
  • Drug tests (3 tests) – $49 – $69
  • Fertility (3 tests) – $69 – $139
MyLab box testing kit

Best microbiome test

  1. Viome
  2. Thryve
  3. BIOHM

Viome

Summary

Viome’s flagship product is their Gut Intelligence Test, sold in every state in the United States except New York. This commercial gut microbiome test was designed to provide customers with personal diet and wellness recommendations. 

Whereas most genetic testing companies sequence DNA, Viome uses RNA sequencing to selectiving analyze a small portion of the microbial genome. Sequencing identifies the types of microbes that are living in your gut, which guides their health and helps identify food for diet recommendations. Some common issues with this type of genetic testing include small RNA databases to which to compare samples and inaccuracies of identifying similar microbes. 

Reporting
  • Diet recommendations
    • Superfoods
    • Enjoy foods
    • Avoid foods
  • Qualitative assessment (good – needs improvement) of gut-specific health
Cost

Gut Intelligence Test: $149

Viome Gut Intelligence testing kit

Thryve

Summary

Thryve is a health and wellness company that provides gut health testing and personalized diet and probiotic recommendations. The company’s gut health reports are intended to compliment their recommendations. It should be noted that probiotics are not typically reviewed by the Food and Drug Administration (FDA). 

Thryve sequences and the RNA of the bacteria in a stool sample to identify the microbial community in a customer’s gut. This data is analyzed and a Gut Health Report, Food Plan, and probiotic product recommendations are generated. Thryve offers five different probiotic supplements that can be purchased individually. Alternatively, customers who take the Gut Health Test can order personalized probiotic blends made as a mix of the strains in the other supplements. 

Probiotics are essentially collections of gut bacteria. Depending on the identity of the gut microbes analyzed, companies like Thryve can recommend collections that will best supplement the community already present based on customer health goals.

Reporting*
  • Identification of gut bacteria
  • Wellness score to quantify gut health
  • Diet and supplement recommendations

*Returned via an app

Cost
  • Gut Health Test – $99
  • Supplements: $39 per month
Thryve testing kit

BIOHM

Summary

BIOHM is a health and wellness company that provides products supporting both bacteria and fungi in the gut. The first BIOHM probiotic supplement was designed to counter digestive plaque that builds up in the gut. They now sell additional probiotics and have added prebiotics. Most supplement companies only focus on bacteria. BIOHM’s goal is to help customers improve their overall health by delivering products that balance both bacteria and fungi. 

The company also developed a DNA test for digestive system health in which customers can sequence the DNA to identify the bacteria and fungi populating their gut. Based on these results, customers receive personalized supplement recommendations designed by registered nutritionists who review the report. 

Reporting
  • Overall gut score
  • Comparison 
  • Your gut’s bacterial and fungal communities
  • Actionable recommendations
Cost
  • Gut Test – $129
  • Supplements – $24.99 – $44.99
BIOHM gut test kit

Best dog DNA tests

Coming soon!

Best cat DNA test

Coming soon!

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