Genome-Wide Association Study (GWAS)
Nebula Genomics

Longevity (Timmers, 2020)

STUDY TITLE: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing SUMMARY: Identification of 10 genetic variants associated with longevity. OVERVIEW: Longevity is a trait that is defined as having a longer lifespan than most people. This study specifically defined longevity as living longer than 90% of people. Though factors such as

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Parental Lifespan (Timmers, 2020)

STUDY TITLE: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing SUMMARY: Identification of 10 genetic variants linked to parental lifespan. OVERVIEW: Worldwide, the average lifespan is 70 years for males and 72 years for females. Many people, though, live well into their 90s or 100s. Though factors such as diet and

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Healthspan (Timmers, 2020)

STUDY TITLE: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing SUMMARY: Identification of 10 genetics variants associated with healthspan, or the number of years in good health. OVERVIEW: Aging is an inevitable part of life. While we may all want to live longer, we don’t want our final years to be

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two red dice
Genome-Wide Association Study (GWAS)
Nebula Genomics

Gambling disorders (Lind, 2012)

STUDY TITLE: Genome-wide Association Study of a Quantitative Disordered Gambling Trait SUMMARY: Discovery of 6 genetic variants associated with the development of gambling disorders. OVERVIEW: When most people think of gambling, they typically think of casinos or lottery tickets. But, gambling comes in many more forms. Even activities such as playing bingo can be considered

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Inflammatory protein level (Hillary, 2020)

STUDY TITLE: Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults SUMMARY: Identification of 16 genetic variants associated with the presence of inflammatory proteins in the blood. OVERVIEW: Inflammation is a response of the immune system to an infection or injury. It is caused by a release of inflammatory proteins that

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Tourette’s syndrome (Yu, 2019)

STUDY TITLE: Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies SUMMARY: Discovery of multiple genetic variants associated with Tourette’s Syndrome. OVERVIEW: Tourette’s syndrome is a disorder of the nervous system characterized by uncontrollable movements or sounds that are known as tics. It affects about 1 out of every

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Anxiety (Meier, 2019)

STUDY TITLE: Genetic Variants Associated With Anxiety and Stress-Related Disorders SUMMARY: Identification of genetic variants near the PDE4B gene that are associated with anxiety and stress disorders. OVERVIEW: Anxiety disorders, where a person experiences excessive and inappropriate fear and anxiety, affect more than 20% of people at some point in their lives. Although stress-related disorders

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black and white photograph of woman's neck
Genome-Wide Association Study (GWAS)
Nebula Genomics

Autoimmune thyroid disease (Saevarsdottir, 2020)

STUDY TITLE: FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease SUMMARY: Identification of 99 genetic variants associated with autoimmune thyroid disease. OVERVIEW: The human immune system evolved to defend our bodies against disease-causing microorganisms. However, sometimes a person’s immune system may attack the body’s own cells, causing an autoimmune disease.

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Chronic wound microbiome diversity (Tipton, 2020)

STUDY TITLE: Patient genetics is linked to chronic wound microbiome composition and healing SUMMARY: Identification of 6 genetic variants that explain variation in wound microbiome diversity, a critical factor in the wound healing process. OVERVIEW: Normally wounds heal in a matter of weeks or months, often forming scar tissue over the site of injury. Chronic wounds are

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model of brain and neuron
Genome-Wide Association Study (GWAS)
Nebula Genomics

Brain lesions (Armstrong, 2020)

STUDY TITLE: Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities SUMMARY: Discovery of 11 genomic regions associated with periventricular white matter hyperintensities that indicate brain lesions. OVERVIEW: The brain is a delicate organ that requires constant blood flow. Strokes occur when a large part of the brain is no longer

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closeup of eye
Genome-Wide Association Study (GWAS)
Nebula Genomics

Corneal thickness (Choquet, 2020)

STUDY TITLE: A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness SUMMARY: Identification of over 40 new genetic variants associated with central corneal thickness, which is linked to multiple disorders of the eye. OVERVIEW: The cornea acts like a “window” for the eye, allowing light to enter while

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spoon filled with sugar
Genome-Wide Association Study (GWAS)
Nebula Genomics

Type 2 diabetes (Vujikovic, 2020)

STUDY TITLE: Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis SUMMARY: Discovery of 568 novel genomic regions associated with type 2 diabetes in a multi-ethnic study. OVERVIEW: Insulin is a hormone that promotes cells to intake sugar from the blood. People

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Thinness (Orthofer, 2020)

STUDY TITLE: Identification of ALK in Thinness SUMMARY: Discovery of 5 genetic variants associated with thinness. OVERVIEW: Although diet and exercise are important for maintaining healthy body weight, individuals who eat similar foods and exercise similar amounts can differ in their weight. Most studies that look for genetic variants associated with the body mass index (BMI) compare

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Long QT Syndrome (Lahrouchi, 2020)

STUDY TITLE: Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome SUMMARY: Identification of 3 genomic regions associated with long QT syndrome. OVERVIEW: The heartbeat is controlled by electrical impulses which normally pause between beats. During that pause, the heart muscles recharge for the next beat. If this

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Triple-negative breast cancer (Zhang, 2020)

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with triple-negative breast cancer. OVERVIEW: Breasts are complex structures with multiple cell types which can give rise to multiple types of cancer. Breast cancers are classified by what receptors cancer cells have on

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