WEEKLY UPDATE: March 9, 2020
SUMMARY: Identification of 71 genetic variants associated with Crohn’s disease.
OVERVIEW: Crohn’s disease is a type of inflammatory bowel disease, a condition characterized by chronic inflammation of the digestive tract. Nearly a million individuals in the United States alone are affected by Crohn’s disease. Typical symptoms are pain, diarrhea and weight loss. To better understand the genetics of Crohn’s disease, this study examined over 40,000 individuals of European descent. The analysis uncovered 71 Crohn’s disease-associated genetic variants, including 39 variants that are reported for the first time. Together, these 71 variants explain about 23% of the heritability of Crohn’s disease. Many of the identified genetic variants are near genes that play a role in controlling the body’s immune system. Some of these genes have been previously implicated in other inflammatory conditions such as ulcerative colitis and rheumatoid arthritis.
DID YOU KNOW? Because there is no cure for Crohn’s disease, the condition is commonly managed through incorporating lifestyle changes that reduce inflammation. This may include dietary changes, such as limiting the intake of fats and dairy while increasing fiber consumption. [SOURCE]
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ANALYZED VARIANTS: rs2076756, rs11209026, rs3792109, rs4077515, rs11742570, rs1250550, rs2413583, rs10761659, rs11564258, rs12521868, rs4409764, rs17293632, rs7714584, rs6651252, rs8005161, rs3197999, rs1819658, rs181359, rs3810936, rs7517810, rs4809330, rs1893217, rs10495903, rs3024505, rs2838519, rs6556412, rs10758669, rs3091315, rs3180018, rs7423615, rs7927997, rs12720356, rs4871611, rs2058660, rs359457, rs415890, rs7702331, rs713875, rs281379, rs740495, rs1736020, rs151181, rs102275, rs212388, rs1799964, rs780093, rs2549794, rs3764147, rs4902642, rs2062305, rs694739, rs13428812, rs12242110, rs2872507, rs11167764, rs12722489, rs6738825, rs2476601, rs1847472, rs10181042, rs13073817, rs17309827, rs2797685, rs1998598, rs736289, rs1456896, rs6908425, rs11871801, rs6568421