7 Facts from our Dante Labs review
- Location: L’Aquila, Italy
- Products: whole genome sequencing, whole exome sequencing
- Reporting: Health, Wellness, Nutrigenomics, Fitness and Pharmacogenetics reports
- Raw data download: available for download in FASTQ, BAM and VCF formats
- Privacy: GDPR-compliant; in-house lab in Italy
- Cost: $599 for 30x whole genome sequencing, most reports cost extra ($49 – $499)
- Alternatives: Nebula Genomics (30x whole genome sequencing for $299), Veritas Genetics (30x whole genome sequencing for $599 – $3599)
Dante Labs was founded in 2016 by Mattia Capulli and Andrea Riposati after being approached by a friend who had difficulty finding a Whole Genome Sequencing test. The company’s goal is to make personal genomics accessible to everyone so that people can make informed decisions about their health. Dante Labs is headquartered in L’Aquila, Italy with an office in New York in the United States as well. They have customers in more than 80 countries. Learn more in our Dante Labs review!
Whole Genome Sequencing (WGS)
Whole Genome Sequencing (WGS) based on next-generation sequencing technology is the new gold standard for genetic testing. Most DNA testing companies such as 23andMe and Ancestry analyze less than 0.02% of the DNA. Dante Labs whole genome sequencing decodes 100% of the DNA using whole genome sequencing at 30x coverage. This fully determines an individual’s genetic makeup. It uses Illumina’s NovaSeq™ 6000 System for high throughput genomic testing.
Taking the Dante Labs test
Before we review Dante Labs products, let’s take a look at how to order Dante Labs tests. The test can be ordered online and comes with a kit ID number. This identifier is used as a future reference for reporting and other correspondence. The sample kit arrives in a box with a collection vial, instructions, and a return shipping label. Dante Labs requires a saliva sample and it is recommended to not eat, drink, smoke, brush teeth or chew gum for 30 minutes before collecting the sample. For younger children, a cheek swab kit can be requested by sending Dante Labs an email after placing the order. Before sending the samples back in the mail, the saliva collection kit needs to be registered online in Dante Lab’s Genome Manager. This is an online portal that allows the customer to access reports and raw DNA files.
Review of Dante Labs products
Dante Labs offer two different tests, both of which offer full genome coverage, and an advanced option to upgrade. Additional reports can also be ordered to supplement the DNA Test report.
Dante Labs Whole Genome Sequencing Test (30x) (starting from $599)
This test sequenced 100% of the DNA at 30x coverage. The standard reporting time for this test is 8 weeks. For expedited service, this test is available for $899 with a turnaround time of 2 weeks.
Whole GenomeZ – Whole Genome Sequencing for Advanced Analysis (130x + 30x) (starting from $849)
This test kit provides 130x coverage of the exome. The exome is the protein-coding regions of the DNA. More than 85% of the known mutations that cause diseases occur in the exome. The rest of the genome is sequenced with 30X coverage. The reports can be made available in 2 weeks for $1,490.
Whole Genome Hybrid Upgrade (130x + 30x + 15x) ($1,399)
This test combines whole genome sequencing at 30x, whole exome sequencing at 130x coverage and long-read sequencing at 15x coverage. Long read sequencing is done using Oxford Nanopore machines. It is a new sequencing technology that produces much longer reads which facilitates assembly of repetitive genomic regions.
Review of Dante Labs reporting
Now, let’s review Dante Labs reporting. A customer creates an account by registering their kit in the Genome Manager. Here the customer can check the status of the order, review all reports, explore the genome, download raw data and purchase new reports.
The reports that are included in the initial price are categorized into Wellness and Lifestyle, Nutrigenomics, Pharmacogenetics (Drug Reaction) categories. All the conditions analyzed can be found here.
Dante Labs Wellness and Lifestyle Report
This report lists diseases that the customer is more likely to develop. The report summarizes the health conditions analyzed and highlights any high risk or medium risk conditions. The name of this reporting package is somewhat misleading because it actually contains many reports on severe, rare diseases caused by highly pathogenic variants.
Dane Labs Pharmacogenetics Report
The report identifies genetic predispositions towards the failure of response to drugs or adverse reactions from the administration of the drug. One caveat with the pharmacogenetics report is that it is not available for customers in the United States. This is because Dante Labs has not complied with US Food and Drug Administration (FDA) regulations.
Dante Labs Nutrigenomics Report
This report helps the customer formulate a plan to optimize their diet and live a longer, more vibrant life. The report summarizes the effects of specific genetic variants on metabolism or eating behavior and advice on how to include different nutrients in the diet. There are different sections on macronutrients, micronutrients, eating habits, taste and reactions, and body weight.
Customized reports are available to patients who have a strong, justified interest for a specific condition or disease.
Additional DNA test reports and many genetic diseases are available for a price of $49 each. Those costs are not included in the price of the testing kit (e.g. $599 for whole genome sequencing). Many of these reports focus on specific disease categories such as cardiovascular, dermatology, endocrinology, neurology and autism. Available additional reports can be seen here and sample reports can be downloaded here.
Genome Analysis Subscription
Customers can also subscribe to receive updated versions of the reports every month. The bronze service is available for €4.99/month ($5.40/month). The silver service for €19.99/month ($21.61/month) and includes one additional credit towards a new report. The gold service costs €39.99/month ($43.24/month) and includes two additional credits towards new reports every month.
Access to raw genetic data
The sequencing results are available for download. It includes FASTQ files, BAM files and VCF files. Note, that BAM and FASTQ files are very large so downloading them might not be possible with a slow internet connection.
Privacy and security
Dante Labs is compliant with the EU General Data Protection Regulation (GDPR) and the UK Cyber Essentials.
Dante Labs in the news
Let’s review Dante Labs news coverage.
In early 2018, there were 5 reported cases of Dante Labs sending used kits to customers.
Also, in 2018, Dante Labs also announced the expansion of their WGS testing with the analysis of Mitochondrial DNA (mtDNA) for advanced ability to detect and identify a range of neurological diseases.
In January 2020, Dante Labs announced a partnership with BC Platforms, a world leader in genomic data management and analytics, to automate and streamline their genomic data management.
Later in 2020, Dante Labs announced a program to support global scientific research on Coronavirus, offering free genome sequencing services to research projects on Coronavirus across the world. This is open to researchers, scientists, research organizations and universities.
Dante Labs Pros and Cons
- 30X Whole Genome Sequencing
- Option for 130X at genes
- Download raw DNA data files
- In-house sequencing facility
- Services available globally
- Cost of additional reports can add up quickly
- Reports of unresponsive customer service
- Cheaper alternatives available
Dante Labs Reviews
- Dante Labs reviews on Trustpilot: 3.5/5
- Dante Labs reviews on DNA Testing Choice: 4.5/5
- See what people are asking on Reddit
- Check out #DanteLabs on Twitter
While Dante Labs reviews are mostly positive, many customers have complained about delays in receiving their results. Many customers have also complained about lackluster customer service, with no responses to their emails or any notifications of the progress of their sequencing. There have been several cases of customer resequencing requests being ignored as well. Dante Labs have responded to complaints, claiming that there have been no more delays since they opened their own sequencing laboratory
We finish our Dante Labs review with a comparison to Nebula Genomics and other DNA testing companies. Whole genome sequencing with Dante Labs costs $599 and the costs quickly add up because there are dozens of additional reports that cost $49 each. Nebula Genomics offers 30x for only $299 which includes comprehensive reports in Nebula Research Library and weekly updates. We believe the journey of learning about yourself through your DNA shouldn’t end with a one-time report!
|23andMe||AncestryDNA||Nebula Genomics||Dante Labs|
|Price||$99-199||$99-149||$299 (plus a subscription fee for weekly updates)||$599 -1,399 (plus $49 for additional reports and a subscription fee)|
|Technology||genotyping||genotyping||30x whole genome sequencing||30x whole genome sequencing|
|Test report||single||single||weekly updates based on the latest scientific discoveries||additional reports for a fee|
|Data exploration||limited||limited||multiple browser-based genome exploration tools||IGV genome browser|
|Free DNA data upload||No||No||Yes||No|
|Ancestry analysis||Yes||Yes||Deep ancestry analysis in partnership with FTDNA||No|
Dante Labs vs 23andMe vs AncestryDNA vs Nebula Genomics