ilustración del corazón humano

Nivel de apolipoproteína A-1 (Richardson, 2020)

TÍTULO DE ESTUDIO: Evaluar la relación entre los lípidos de lipoproteínas circulantes y las apolipoproteínas con el riesgo de enfermedad coronaria: Un análisis de aleatorización mendeliano multivariable

RESUMEN: Identificación de 440 variantes genéticas asociadas al nivel de apolipoproteína A-1 en la sangre y análisis de su contribución al riesgo de enfermedades coronarias.

DESCRIPCIÓN: La enfermedad coronaria (CHD) es una condición que se desarrolla cuando las arterias del corazón no pueden suministrar suficiente oxígeno al músculo cardíaco. La enfermedad coronaria es la principal causa de muerte en los Estados Unidos. Se produce cuando placa se acumula en las arterias del corazón y bloquea el flujo de sangre al corazón. Arterial placa consiste en múltiples sustancias que circulan en la sangre, en particular las grasas y colesterol. Grasas y colesterol no pueden viajar por el torrente sanguíneo por sí mismos y en su lugar deben ser transportados por proteínas llamadas "apolipoproteínas". La apolipoproteína responsable de transportar el HDL colesterol...o el "bueno"... colesterolen la sangre se conoce como apolipoproteína A-1 (apoA1). Debido a su papel, los niveles elevados de apolipoproteína A-1 pueden sugerir un efecto protector contra el desarrollo de enfermedades coronarias. En este estudio se examinaron los datos genéticos de más de 440.000 personas de ascendencia europea para identificar las regiones genómicas asociadas con los niveles de apolipoproteína A-1 en la sangre. Los investigadores identificaron 440 variantes genéticas, incluidas 407 variantes nuevas, asociadas con los niveles de apolipoproteína A-1.

¿SABÍAS? Además de su efecto protector contra el desarrollo de enfermedades coronarias, los niveles elevados de apolipoproteína A-1 también pueden estar asociados con un menor riesgo de demencia y otros trastornos neurodegenerativos. [FUENTE]

RESULTADOS DE LA MUESTRA: Aprenda más sobre el Biblioteca de investigación de nebulosa.

Resultados de la muestra para el nivel de apolipoproteína A-1

VARIANTES ASOCIADAS AL NIVEL DE APOLIPOPROTEÍNA A-1: rs9704692, rs3014246, rs12984021, rs72647336, rs10458643, rs72729623, rs61596977, rs36096231, rs848638, rs34184910, rs6969773, rs4441609, rs13111599, rs72755439, rs62135193, rs7835108, rs62555197, rs1540687, rs8135417, rs1862205, rs9989466, rs9866679, rs2698737, rs17191491, rs1400362, rs144475339, rs6458867, rs77947762, rs74333499, rs28824216, rs11245482, rs12938061, rs9347737, rs61748951, rs2343593, rs1045241, rs12987470, rs115660648, rs17039171, rs9559901, rs10748165, rs74963256, rs73375614, rs7036107, rs212100, rs111849006, rs10950390, rs7784748, rs12436555, rs248653, rs113710278, rs75988962, rs10978335, rs7119167, rs2204886, rs78937603, rs13411625, rs116857878, rs3897473, rs12598179, rs75246752, rs11973318, rs71421262, rs141478056, rs74456742, rs62405458, rs7514202, rs10036789, rs34180494, rs1852922, rs13024140, rs12357890, rs804553, rs32578, rs117739035, rs11883967, rs2159935, rs1718859, rs16844296, rs62369484, rs2544654, rs186586197, rs1834144, rs34642857, rs4450131, rs145184406, rs78359342, rs59038405, rs117399007, rs12204488, rs4725969, rs12867032, rs6785881, rs351862, rs1919309, rs11159261, rs352126, rs59137082, rs11690597, rs4652192, rs12449758, rs4474021, rs2540951, rs12292135, rs112942650, rs74913239, rs10947786, rs55801554, rs12044156, rs7192161, rs71355297, rs11202154, rs4820346, rs77234291, rs73457437, rs514924, rs374039502, rs79506257, rs4676609, rs1862069, rs13300004, rs10504477, rs7251640, rs587739738, rs56196860, rs6532796, rs17740942, rs117230571, rs6807935, rs3859588, rs11691486, rs75663391, rs73082723, rs11780610, rs79009737, rs144033177, rs515756, rs36089024, rs143474489, rs731758, rs6467595, rs56263064, rs55710224, rs12411959, rs13144764, rs4762756, rs41292412, rs17321999, rs7757193, rs185073199, rs4654395, rs34955778, rs12975319, rs35624680, rs4875043, rs62114506, rs55652051, rs140164052, rs34830321, rs2520096, rs112771035, rs112233856, rs60667919, rs11066320, rs8075019, rs2246012, rs12510382, rs10752898, rs49675, rs7304603, rs7700617, rs74419430, rs11021232, rs72796869, rs8039305, rs7134035, rs62271373, rs12810864, rs142958146, rs12045101, rs147525635, rs3814883, rs17008972, rs28567061, rs59586387, rs13108218, rs1986868, rs2395617, rs9604045, rs6430954, rs6059958, rs12546096, rs1395221, rs4999718, rs15052, rs11641548, rs13097947, rs34712273, rs7304462, rs76428106, rs1406982, rs2972166, rs56105022, rs10012624, rs6507716, rs7503353, rs3760230, rs116006942, rs12263369, rs10023962, rs6686889, rs1086056, rs2247355, rs35650976, rs2700892, rs4714554, rs6123685, rs557675, rs4599108, rs79940707, rs1037117, rs80236739, rs74500135, rs56090699, rs11591147, rs183078, rs28362901, rs36090449, rs78608249, rs73578509, rs76456334, rs72926946, rs11170517, rs7259070, rs2804894, rs6062510, rs73052033, rs1771582, rs33042, rs150237291, rs10745954, rs4648892, rs61805076, rs11605837, rs112672290, rs3747973, rs10489044, rs9980311, rs2982521, rs34942359, rs6977416, rs2963472, rs35007880, rs2111705, rs77631377, rs10419198, rs7546242, rs367677, rs9608972, rs7170463, rs1468642, rs62203108, rs7896518, rs681869, rs1611719, rs138354839, rs9884482, rs72823014, rs34555420, rs78595810, rs1864167, rs10798615, rs4979372, rs72959041, rs7943699, rs10507274, rs286965, rs4871603, rs1055582, rs3915932, rs3740688, rs77542162, rs17326656, rs13326165, rs34767118, rs7953249, rs12273363, rs4632228, rs34138141, rs73216700, rs1446585, rs59104589, rs4930352, rs150483923, rs6448429, rs9916613, rs3184504, rs4356188, rs56271783, rs254559, rs66757203, rs2069945, rs11601507, rs1043897, rs9817452, rs2923078, rs804267, rs9426827, rs35137994, rs450244, rs74444445, rs3936511, rs11057390, rs589942, rs6499102, rs11045172, rs3798233, rs12229372, rs75406471, rs75152587, rs1583974, rs115744844, rs4273010, rs78025076, rs3732356, rs141949189, rs13402475, rs2965169, rs7186799, rs989075, rs738409, rs35715914, rs118024629, rs7238484, rs3749748, rs698927, rs557933, rs13379043, rs10955991, rs568551048, rs133015, rs976002, rs16953475, rs11227582, rs58473820, rs9393926, rs117687565, rs6765484, rs11228871, rs75265117, rs2297402, rs9769088, rs12224170, rs12422125, rs1132274, rs76213248, rs2071379, rs114760566, rs4239651, rs235314, rs8103728, rs2523978, rs34397747, rs2298624, rs11067231, rs2419605, rs10883451, rs145276599, rs1047964, rs112001035, rs41272086, rs1107850, rs1716393, rs73119306, rs635634, rs1047891, rs150844304, rs1877031, rs3800461, rs1364422, rs10951983, rs36057735, rs4784709, rs61789561, rs11089620, rs1260326, rs17138358, rs78058190, rs7136506, rs2395158, rs2925979, rs2642438, rs9471972, rs17520254, rs7817574, rs267738, rs10846497, rs7222619, rs3802548, rs2494748, rs140584594, rs4775033, rs2943645, rs367070, rs559355, rs2269434, rs59347135, rs174566, rs2792751, rs3768321, rs921919, rs6469605, rs144311893, rs12976395, rs55781197, rs2066714, rs116843064, rs12740374, rs13107325, rs139915535, rs686030, rs737338, rs12074528, rs11789603, rs676210, rs9987289, rs72836561, rs79984435, rs1800961, rs2281718, rs11632618, rs1318175, rs2740488, rs8086351, rs429358, rs613808, rs77960347, rs331, rs1601933, rs9989419

RECURSOS ADICIONALES:
Enfermedad coronaria (Video)
Enfermedad coronaria
Wikipedia

ACTUALIZACIÓN SEMANAL: 5 de abril de 2020

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