Nivel de apolipoproteína A-1 (Richardson, 2020)

TÍTULO DEL ESTUDIO: Evaluación de la relación entre los lípidos de lipoproteínas circulantes y las apolipoproteínas con el riesgo de enfermedad coronaria: un análisis de aleatorización mendeliana multivariable

RESUMEN: Identificación de 440 variantes genéticas asociadas al nivel de apolipoproteína A-1 en sangre y análisis de su contribución al riesgo de enfermedad coronaria.

DESCRIPCIÓN: La enfermedad cardíaca coronaria (CHD) es una afección que se desarrolla cuando las arterias del corazón no pueden suministrar suficiente oxígeno al músculo cardíaco. La enfermedad coronaria es la principal causa de muerte en los Estados Unidos. Ocurre cuando placa se acumula en las arterias del corazón y bloquea el flujo sanguíneo al corazón. Arterial placa consta de múltiples sustancias que circulan en la sangre, en particular grasas y colesterol . Grasas y colesterol no pueden viajar por el torrente sanguíneo por sí mismos y en su lugar deben ser transportados por proteínas llamadas “apolipoproteínas”. La apolipoproteína responsable de transportar HDL colesterol , o el «bueno» colesterol , en la sangre se conoce como apolipoproteína A-1 (apoA1). Debido a su función, los niveles elevados de apolipoproteína A-1 pueden sugerir un efecto protector contra el desarrollo de enfermedad coronaria. Este estudio examinó los datos genéticos de más de 440.000 personas de ascendencia europea para identificar las regiones genómicas asociadas con los niveles de apolipoproteína A-1 en la sangre. Los investigadores identificaron 440 variantes genéticas, incluidas 407 variantes nuevas, asociadas con los niveles de apolipoproteína A-1.

¿SABÍAS? Además de su efecto protector contra el desarrollo de enfermedad coronaria, los niveles elevados de apolipoproteína A-1 también pueden estar asociados con un menor riesgo de demencia y otros trastornos neurodegenerativos. [SOURCE]

RESULTADOS DE LA MUESTRA: Más información sobre el Biblioteca de investigación de nebulosa .

Resultados de la muestra para el nivel de apolipoproteína A-1

VARIANTES ASOCIADAS AL NIVEL DE APOLIPOPROTEÍNA A-1: rs9704692, rs3014246, rs12984021, rs72647336, rs10458643, rs72729623, rs61596977, rs36096231, rs848638, rs34184910, rs6969773, rs4441609, rs13111599, rs72755439, rs62135193, rs7835108, rs62555197, rs1540687, rs8135417, rs1862205, rs9989466, rs9866679, rs2698737, rs17191491, rs1400362, rs144475339, rs6458867, rs77947762, rs74333499, rs28824216, rs11245482, rs12938061, rs9347737, rs61748951, rs2343593, rs1045241, rs12987470, rs115660648, rs17039171, rs9559901, rs10748165, rs74963256, rs73375614, rs7036107, rs212100, rs111849006, rs10950390, rs7784748, rs12436555, rs248653, rs113710278, rs75988962, rs10978335, rs7119167, rs2204886, rs78937603, rs13411625, rs116857878, rs3897473, rs12598179, rs75246752, rs11973318, rs71421262, rs141478056, rs74456742, rs62405458, rs7514202, rs10036789, rs34180494, rs1852922, rs13024140, rs12357890, rs804553, rs32578, rs117739035, rs11883967, rs2159935, rs1718859, rs16844296, rs62369484, rs2544654, rs186586197, rs1834144, rs34642857, rs4450131, rs145184406, rs78359342, rs59038405, rs117399007, rs12204488, rs4725969, rs12867032, rs6785881, rs351862, rs1919309, rs11159261, rs352126, rs59137082, rs11690597, rs4652192, rs12449758, rs4474021, rs2540951, rs12292135, rs112942650, rs74913239, rs10947786, rs55801554, rs12044156, rs7192161, rs71355297, rs11202154, rs4820346, rs77234291, rs73457437, rs514924, rs374039502, rs79506257, rs4676609, rs1862069, rs13300004, rs10504477, rs7251640, rs587739738, rs56196860, rs6532796, rs17740942, rs117230571, rs6807935, rs3859588, rs11691486, rs75663391, rs73082723, rs11780610, rs79009737, rs144033177, rs515756, rs36089024, rs143474489, rs731758, rs6467595, rs56263064, rs55710224, rs12411959, rs13144764, rs4762756, rs41292412, rs17321999, rs7757193, rs185073199, rs4654395, rs34955778, rs12975319, rs35624680, rs4875043, rs62114506, rs55652051, rs140164052, rs34830321, rs2520096, rs112771035, rs112233856, rs60667919, rs11066320, rs8075019, rs2246012, rs12510382, rs10752898, rs49675, rs7304603, rs7700617, rs744 19430, rs11021232, rs72796869, rs8039305, rs7134035, rs62271373, rs12810864, rs142958146, rs12045101, rs147525635, rs3814883, rs17008972, rs28567061, rs59586387, rs13108218, rs1986868, rs2395617, rs9604045, rs6430954, rs6059958, rs12546096, rs1395221, rs4999718, rs15052, rs11641548, rs13097947, rs34712273, rs7304462, rs76428106, rs1406982, rs2972166, rs56105022, rs10012624, rs6507716, rs7503353, rs3760230, rs116006942, rs12263369, rs10023962, rs6686889, rs1086056, rs2247355, rs35650976, rs2700892, rs4714554, rs6123685, rs557675, rs4599108, rs79940707, rs1037117, rs80236739, rs74500135, rs56090699, rs11591147, rs183078, rs28362901, rs36090449, rs78608249, rs73578509, rs76456334, rs72926946, rs11170517, rs7259070, rs2804894, rs6062510, rs73052033, rs1771582, rs33042, rs150237291, rs10745954, rs4648892, rs61805076, rs11605837, rs112672290, rs3747973, rs10489044, rs9980311, rs2982521, rs34942359, rs6977416, rs2963472, rs35007880, rs2111705, rs77631377, rs10419198, rs7546242, rs367677, rs9608972, rs7170463, rs1468642, rs62203108, rs7896518, rs681869, rs1611719, rs138354839, rs9884482, rs72823014, rs34555420, rs78595810, rs1864167, rs10798615, rs4979372, rs72959041, rs7943699, rs10507274, rs286965, rs4871603, rs1055582, rs3915932, rs3740688, rs77542162, rs17326656, rs13326165, rs34767118, rs7953249, rs12273363, rs4632228, rs34138141, rs73216700, rs1446585, rs59104589, rs4930352, rs150483923, rs6448429, rs9916613, rs3184504, rs4356188, rs56271783, rs254559, rs66757203, rs2069945, rs11601507, rs1043897, rs9817452, rs2923078, rs804267, rs9426827, rs35137994, rs450244, rs74444445, rs3936511, rs11057390, rs589942, rs6499102, rs11045172, rs3798233, rs12229372, rs75406471, rs75152587, rs1583974, rs115744844, rs4273010, rs78025076, rs3732356, rs141949189, rs13402475, rs2965169, rs7186 799, rs989075, rs738409, rs35715914, rs118024629, rs7238484, rs3749748, rs698927, rs557933, rs13379043, rs10955991, rs568551048, rs133015, rs976002, rs16953475, rs11227582, rs58473820, rs9393926, rs117687565, rs6765484, rs11228871, rs75265117, rs2297402, rs9769088, rs12224170, rs12422125, rs1132274, rs76213248, rs2071379, rs114760566, rs4239651, rs235314, rs8103728, rs2523978, rs34397747, rs2298624, rs11067231, rs2419605, rs10883451, rs145276599, rs1047964, rs112001035, rs41272086, rs1107850, rs1716393, rs73119306, rs635634, rs1047891, rs150844304, rs1877031, rs3800461, rs1364422, rs10951983, rs36057735, rs4784709, rs61789561, rs11089620, rs1260326, rs17138358, rs78058190, rs7136506, rs2395158, rs2925979, rs2642438, rs9471972, rs17520254, rs7817574, rs267738, rs10846497, rs7222619, rs3802548, rs2494748, rs140584594, rs4775033, rs2943645, rs367070, rs559355, rs2269434, rs59347135, rs174566, rs2792751, rs3768321, rs921919, rs6469605, rs144311893, rs12976395, rs55781197, rs2066714, rs1168 43064, rs12740374, rs13107325, rs139915535, rs686030, rs737338, rs12074528, rs11789603, rs676210, rs9987289, rs72836561, rs79984435, rs1800961, rs2281718, rs11632618, rs1318175, rs2740488, rs8086351, rs429358, rs613808, rs77960347, rs331, rs1601933, rs9989419

RECURSOS ADICIONALES:
Enfermedad coronaria (video)
Enfermedad coronaria
Wikipedia

ACTUALIZACIÓN SEMANAL: 5 de abril de 2020

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