black and white photograph of woman's neck
Genome-Wide Association Study (GWAS)
Nebula Genomics

Autoimmune thyroid disease (Saevarsdottir, 2020)

STUDY TITLE: FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease SUMMARY: Identification of 99 genetic variants associated with autoimmune thyroid disease. OVERVIEW: The human immune system evolved to defend our bodies against disease-causing microorganisms. However, sometimes a person’s immune system may attack the body’s own cells, causing an autoimmune disease.

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Chronic wound microbiome diversity (Tipton, 2020)

STUDY TITLE: Patient genetics is linked to chronic wound microbiome composition and healing SUMMARY: Identification of 6 genetic variants that explain variation in wound microbiome diversity, a critical factor in the wound healing process. OVERVIEW: Normally wounds heal in a matter of weeks or months, often forming scar tissue over the site of injury. Chronic wounds are

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model of brain and neuron
Genome-Wide Association Study (GWAS)
Nebula Genomics

Brain lesions (Armstrong, 2020)

STUDY TITLE: Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities SUMMARY: Discovery of 11 genomic regions associated with periventricular white matter hyperintensities that indicate brain lesions. OVERVIEW: The brain is a delicate organ that requires constant blood flow. Strokes occur when a large part of the brain is no longer

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closeup of eye
Genome-Wide Association Study (GWAS)
Nebula Genomics

Corneal thickness (Choquet, 2020)

STUDY TITLE: A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness SUMMARY: Identification of over 40 new genetic variants associated with central corneal thickness, which is linked to multiple disorders of the eye. OVERVIEW: The cornea acts like a “window” for the eye, allowing light to enter while

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spoon filled with sugar
Genome-Wide Association Study (GWAS)
Nebula Genomics

Type 2 diabetes (Vujikovic, 2020)

STUDY TITLE: Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis SUMMARY: Discovery of 568 novel genomic regions associated with type 2 diabetes in a multi-ethnic study. OVERVIEW: Insulin is a hormone that promotes cells to intake sugar from the blood. People

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Thinness (Orthofer, 2020)

STUDY TITLE: Identification of ALK in Thinness SUMMARY: Discovery of 5 genetic variants associated with thinness. OVERVIEW: Although diet and exercise are important for maintaining healthy body weight, individuals who eat similar foods and exercise similar amounts can differ in their weight. Most studies that look for genetic variants associated with the body mass index (BMI) compare

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Long QT Syndrome (Lahrouchi, 2020)

STUDY TITLE: Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome SUMMARY: Identification of 3 genomic regions associated with long QT syndrome. OVERVIEW: The heartbeat is controlled by electrical impulses which normally pause between beats. During that pause, the heart muscles recharge for the next beat. If this

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Triple-negative breast cancer (Zhang, 2020)

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with triple-negative breast cancer. OVERVIEW: Breasts are complex structures with multiple cell types which can give rise to multiple types of cancer. Breast cancers are classified by what receptors cancer cells have on

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Genome-Wide Association Study (GWAS)
Nebula Genomics

HER2-enriched-like breast cancer (Zhang, 2020)

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with HER2-enriched-like breast cancer. OVERVIEW: Breasts are complex structures with multiple cell types which can give rise to multiple types of cancer. Breast cancers are classified by what receptors cancer cells have on

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Luminal B-like breast cancer (Zhang, 2020)

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with luminal B-like breast cancer. OVERVIEW: Breasts are complex structures with multiple cell types which can give rise to multiple types of cancer. Breast cancers are classified by what receptors cancer cells have

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Luminal B/HER2-negative-like breast cancer (Zhang, 2020)

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with luminal B/HER2-negative-like breast cancer. OVERVIEW: Among women, breast cancer is the second most common type of cancer. In fact, about 13% of women in the United States develop breast cancer

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Genome-Wide Association Study (GWAS)
Nebula Genomics

Luminal A-like breast cancer (Zhang, 2020)

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with luminal A-like breast cancer. OVERVIEW: Among women, breast cancer is the second most common type of cancer. In fact, about 13% of women in the United States develop breast cancer

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Genome-Wide Association Study (GWAS)
Nebula Genomics

PR interval (Ntalla, 2020)

STUDY TITLE: Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction SUMMARY: Discovery of 202 regions of the genome associated with the heart’s PR interval duration. OVERVIEW: The heart beats at regular intervals to pump blood through the body. To control the timing of a heartbeat, the heart relies on a

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person holding loaf of bread
Genome-Wide Association Study (GWAS)
Nebula Genomics

Carbohydrate consumption (Meddens, 2020)

STUDY TITLE: Genomic analysis of diet composition finds novel loci and associations with health and lifestyle SUMMARY: Identification of 13 genetic variants associated with carbohydrate consumption. OVERVIEW: Carbohydrates (carbs) are found in many foods, both healthy and unhealthy, that we regularly consume. The body breaks down carbs into glucose, a sugar that is used as

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sliced butter
Genome-Wide Association Study (GWAS)
Nebula Genomics

Fat consumption (Meddens, 2020)

STUDY TITLE: Genomic analysis of diet composition finds novel loci and associations with health and lifestyle SUMMARY: Identification of 6 genetic variants associated with fat consumption. OVERVIEW: Fats are essential macronutrients that serve as structural building blocks in the body. More specifically, the membranes of our cells are mostly made of fat. Moreover, fats also allow certain vitamins to

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