Taux de cholestérol HDL (Richardson, 2020)

illustration du coeur rose

TITRE DE L’ÉTUDE: Évaluation de la relation entre les lipides lipoprotéiques circulants et les apolipoprotéines avec risque de maladie coronarienne: une analyse randomisée mendélienne multivariée

SOMMAIRE: Identification de 534 variantes génétiques associées au HDL cholestérol taux sanguin et analyse de sa contribution au risque de maladie coronarienne.

LA DESCRIPTION: La maladie coronarienne (CHD) est une maladie qui se développe lorsque les artères du cœur ne peuvent pas fournir suffisamment d’oxygène au muscle cardiaque. La maladie coronarienne est la principale cause de décès aux États-Unis. Cela se produit lorsque plaque s’accumule dans les artères du cœur et bloque le flux sanguin vers le cœur. Artériel plaque se compose de plusieurs substances qui circulent dans le sang. L’une des substances examinées par l’étude est le HDL (lipoprotéine de haute densité) cholestérol , également connu sous le nom de «bon» cholestérol . À cette fin, cette étude a analysé les données génétiques de plus de 440000 individus d’origine européenne pour identifier les régions génomiques associées au HDL. cholestérol niveaux sanguins. Les chercheurs ont identifié 534 variantes génétiques, dont 383 nouvelles variantes, associées au HDL cholestérol les niveaux. L’analyse a montré qu’un HDL élevé cholestérol niveau est associé à une diminution du risque de maladie coronarienne. Cependant, cette association s’est affaiblie lorsque les chercheurs ont pris en compte toutes les graisses et protéines dans l’étude. Les résultats de l’étude suggèrent toujours que le HDL cholestérol joue un rôle important dans le développement des maladies cardiaques.

LE SAVIEZ-VOUS? Le cholestérol HDL est souvent appelé le «bon» cholestérol, car il aide votre corps à éliminer les autres types de cholestérol de la circulation sanguine. Certains moyens d’augmenter le taux de cholestérol HDL comprennent l’exercice et une alimentation pauvre en graisses trans. [SOURCE]

EXEMPLE DE RÉSULTATS: En savoir plus sur Bibliothèque de recherche sur la nébuleuse .

Exemples de résultats pour le taux de cholestérol HDL

VARIANTES ASSOCIES AU NIVEAU DE CHOLESTÉROL HDL: rs9989419, rs1800588, rs1601934, rs343, rs964184, rs77960347, rs8086351, rs79600951, rs2740488, rs72836561, rs2281718, rs116843064, rs429358, rs174566, rs9987289, rs80005209, rs6073958, rs1800961, rs676210, rs11789603, rs13107325, rs1052373, rs2943645, rs10162642, rs12976395, rs921919, rs141469619, rs55781197, rs3768321, RS308, rs571848809, rs367070, rs686030, rs2925979, rs4871603, rs998584, rs75609851, rs737338, rs1054852, rs2792751, rs6469605, rs2066714, rs113740515, rs545858676, rs78058190, rs145276599, rs35493868, rs4731701, rs4969141, rs7136506, rs11658786, rs150844304, rs12422125, rs12224170, rs140584594, rs11228871, rs13389219, rs11228212, rs3184504, rs17138358, rs61352607, rs2263329, rs7817574, rs2256609, rs559355, rs2642438, rs6902116, rs58473820, rs193084249, rs2498786, rs11239536, rs79153732, rs61805075, rs116978226, rs12740374, rs3936511, rs7308864, rs56271783, rs144311893, rs13235365, rs11045171, rs6765484, rs771481, rs75662196, rs9647335, rs112001035, rs11967891, rs427301 0, rs62102718, rs35137994, rs12411732, rs75152587, rs4239651, rs10513801, rs2298624, rs11664369, rs133015, rs72959041, rs10233430, rs2297402, rs6824451, rs61435086, rs72823020, rs12928099, rs1043897, rs1047964, rs3775228, rs11066320, rs2523978, rs17326656, rs2068888, rs77403571, rs632057, rs6542680, rs72647336, rs62271373, rs73243877, rs72926946, rs11645157, rs9817452, rs2159607, rs142288236, rs2307111, rs10955991, rs4871624, rs7750688, rs7757193, rs142493909, rs907866, rs4650994, rs7925100, rs532436, rs267738, rs17309930, rs3129797, rs235314, rs1047891, rs3803501, rs7170463, rs13379043, rs8081548, rs117687565, rs142965311, rs10750766, rs12485478, rs3736802, rs6499102, rs1534696, rs2963468, rs55935382, rs12510382, rs1468642, rs112771035, rs3129962, rs11605837, rs10774579, rs4686739, rs2435307, rs74419430, rs11880219, rs6934962, rs2247355, rs4930352, rs66763009, rs1132274, rs10774439, rs34138141, rs62492368, rs10786114, rs11640494, rs9622830, rs703966, rs2289863, rs74735576, rs3814883, rs557933, rs11658872, rs10846690, rs16928809, rs2804894, rs35777071, rs13097947, rs34675318, rs141062196, rs8014289, rs10504477, rs1168114, rs3763236, rs830620, rs3732356, rs2862954, rs12650112, rs1446585, rs11118320, rs9608972, rs12150914, rs11075985, rs9604045, rs1045241, rs13076933, rs2723065, rs9274346, rs11231138, rs2268840, rs59104589, rs4356188, rs13220570, rs77631377, rs595767, rs77605964, rs3749748, rs41292412, rs116006942, rs367677, rs143474489, rs6457807, rs2298632, rs9657541, rs117230571, rs13269725, rs4979372, rs62112763, rs577525, rs1055582, rs2314338, rs3747973, rs78025076, rs6123685, rs9646167, rs4760, rs28876383, rs2011614, rs1611719, rs10761737, rs7595075, rs7158166, rs4788446, rs1383544876s, r3808774, rs138358166, r3178774, rs1383523976, r3805805, r3805809, r3805809, r3805905, r3805905 rs2237035, rs968050, rs11057468, rs140201358, rs4800356, rs75817747, rs76428106, rs11170516, rs6924387, rs74456742, rs10252234, rs6664374, rs13147189, rs62486442, rs9347737, rs147525635, rs62338910, rs140064750, rs2071379, rs76602912, rs34555420, rs1225053, rs75572195, rs113710278, rs150237291, rs34940374, rs76213248, rs2964007, rs2520096, rs35706812, rs73221948, rs9469583, rs6590207, rs11601507, rs12803463, rs79634051, rs13263821, rs2705616, rs9980311, rs330042, rs11021232, rs11631178, rs12411959, rs1884589, rs113761591, rs12814794, rs2585398, rs374039502, rs72729582, rs2910949, rs67344323, rs2204886, rs74500135, rs11688682, rs16969990, rs11687520, rs1663626, rs13066793, rs62092069, rs13144151, rs838777, rs3733890, rs34695471, rs55652051, rs17740942, rs28712486, rs11254464, rs13042367, rs12045101, rs12975319, rs1771582, rs7583067, rs2781668, rs73457437, rs11878235, rs73082723, rs150300171, rs12516070, rs32578, rs62428831, rs72801474, rs12686780, rs4875043, rs10950390, rs61884030, rs22 98214, rs15052, rs68006638, rs9884482, rs13323506, rs183078, rs4654395, rs78595810, rs17041868, rs61926301, rs185073199, rs7036107, rs72654647, rs112192770, rs200540247, rs248653, rs1240820, rs56105022, rs1086056, rs4078216, rs55801554, rs9877304, rs11043221, rs17566828, rs2417125, rs11883967, rs4947121, rs738409, rs10896581, rs183906992, rs2965169, rs11961755, rs62565259, rs2098918, rs77234291, rs1252425, rs77916918, rs7488780, rs72805692, rs2551980, rs4976033, rs61919816, rs6021914, rs73179655, rs113261881, rs28510484, rs74328314, rs12998038, rs57074291, rs10916239, rs1970811, rs75032664, rs7725218, rs6790951, rs8126001, rs13041173, rs3794752, rs1818917, rs11878604, rs1431659, rs72755439, rs13111599, rs2364723, rs7622114, rs7658082, rs9646934, rs254559, rs12921195, rs1412234, rs34717889, rs61596977, rs1083470, rs11171710, rs73151974, rs76530346, rs58298943, rs9526023, rs17124112, rs115912456, rs7251640, rs10438354, rs3825669, rs16975758, rs6940493, rs34720381, rs1894544, rs549058, rs 8127283, rs75246752, rs34830321, rs1349852, rs10826337, rs7903537, rs1155347, rs117499775, rs2100692, rs4691379, rs11938781, rs1862205, rs141440048, rs2339234, rs57348955, rs6806529, rs12926854, rs567056, rs76246107, rs4855582, rs56017932, rs2245477, rs2645979, rs79311290, rs11653260, rs2534596, rs6874833, rs6131012, rs7650845, rs6059958, rs3859588, rs6987377, rs75479205, rs11009262, rs1395221, rs201441, rs6738438, rs7316878, rs12146566, rs13300004, rs2362541, rs35580606, rs6762415, rs7826177, rs12692596, rs42125, rs6002946, rs680321, rs2750411, rs38166, rs4755720, rs8102873, rs10879184, rs11000468, rs11948445, rs139828053, rs2456722, rs35828909, rs36092527, rs10901802, rs34559316, rs61905599, rs7039168, rs1411432, rs7218647, rs9610329, rs16885512, rs2175766, rs13195251, rs28455602, rs3746915, rs4410790, rs56131490, rs61748951, rs12713007, rs4550673, rs514924, rs79616633, rs4997370, rs1955512, rs4924471, rs12705595, rs6893139, rs144567740, rs2414178, rs11202156, rs1517500, rs17185038, rs2302367, rs11546878, rs1012306, rs2663924, rs3903399, rs61993685, rs117435644, rs7188071, rs2155220, rs12119128, rs11622947, rs502627, rs78456138, rs546436456, rs73455693, rs12986742, rs67934334, rs454968, rs1760940, rs59737437, rs880674, rs1567353, rs445841, rs550916783, rs138026745, rs4233367, rs407133, rs254024, rs118128493

RESSOURCES ADDITIONNELLES:
Maladie coronarienne (vidéo)
Maladie coronarienne
Cholestérol LDL et HDL: Cholestérol «mauvais» et «bon»

MISE À JOUR HEBDOMADAIRE: 5 avril 2020