model of human lungs

Lung cancer (McKay, 2017)

STUDY TITLE: Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

SUMMARY: Identification of 4 novel genomic regions associated with lung cancer.

OVERVIEW: Lung cancer is a condition in which cells in the lungs divide uncontrollably. It is the leading cause of cancer-related deaths in the United States. There are two main types of lung cancer: small cell lung cancer and non-small cell cancer, with the latter comprising 80 to 85% of all lung cancers. Although smoking is the most common risk factor associated with the condition, genetics is also thought to play a role. Therefore, by examining ~85,000 genomes, this study aimed to understand the genetic factors associated with the risk of developing this cancer. The researchers identified 18 genetic variants associated with the condition, 10 of which are novel. Of the novel regions, 4 are associated with lung cancer overall. Some of these regions have been previously associated with addiction and smoking behavior. Overall, the genetic variants identified help explain 8.9% of the heritability of this cancer.

DID YOU KNOW? While smoking is the leading cause of lung cancer, exposure to radon, an invisible, radioactive gas also contributes to the risk. Radon is released from the normal decay of the elements uranium, thorium, and radium in rocks and soil. Houses built on soil rich in these elements can have higher radon levels in the air. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

lung cancer sample results

STUDY-ASSOCIATED VARIANTS: rs55781567, rs56113850, rs11571833, rs71658797, rs6920364, rs11780471, rs66759488

ADDITIONAL RESOURCES:
Cancer in the lungs (Video)
Lung cancer types
Living with lung cancer

WEEKLY UPDATE: May 12, 2020


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