SUMMARY: 12 novel loci have been associated with ADHD in a genome-wide association study of 55,374 individuals.
DESCRIPTION: Attention-deficit/Hyperactivity Disorder (ADHD) is a common behavioral disorder that typically affects a person’s ability to pay attention and control impulsive behaviors. The risk of ADHD is determined by a variety of different genetic and environmental influences. In this genome-wide association study, 12 loci associated with ADHD were identified by examining 55,374 individuals of European ancestry. These loci explain about 22% of the heritability of ADHD. Associations were enriched around genes that are active in the brain as well as conserved genomic regions. The study also observed a genetic correlation of ADHD with reduced educational attainment and depression.
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ADHD-ASSOCIATED VARIANTS: rs11420276, rs1427829, rs212178, rs28411770, rs11591402, rs74760947, rs9677504, rs4916723, rs5886709, rs4858241, rs281324, rs1222063
WEEKLY UPDATE: August 16, 2019