Close-up of a human eye

Age-related macular degeneration (Han, 2020)

STUDY TITLE: Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration

SUMMARY: Identification of 12 novel genomic regions associated with age-related macular degeneration.

OVERVIEW: The retina is the light-sensitive nerve layer that lines the back of the eye. Age-related macular degeneration (ARMD) describes damage to the macula, the area of the retina that is responsible for central, high-resolution, color vision. ARMD, the leading cause of blindness among elderly individuals, affects nearly 160 million people worldwide. This genome-wide association study aimed to identify genetic variants associated with ARMD by examining the genomes of ~132,000 individuals of mostly European descent. The researchers identified 69 genetic variants associated with ARMD, 12 of which are novel. Some of the implicated genes function in inflammatory response pathways and eye traits, such as macular thickness.

DID YOU KNOW? There are two types of macular degeneration: dry and wet. The wet type is characterized by the abnormal growth of blood vessels into the macula. Wet macular degeneration is often treated with drugs that slow down the growth of blood vessels. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

age-related macular degeneration sample results

ARMD-ASSOCIATED VARIANTS: rs800292, rs7542235, rs2248799, rs6428365, rs2672589, rs7555070, rs12116643, rs760070, rs2672590, rs12134610, rs11200607, rs163494, rs7918867, rs4752699, rs4151671, rs10494757, rs4420638, rs1337169, rs12211410, rs5754227, rs1329423, rs247616, rs5754206, rs11076175, rs1998345, rs943080, rs10033900, rs11569520, rs2043085, rs7266392, rs7428936, rs8135665, rs2070895, rs8017304, rs13255394, rs401186, rs11771241, rs13081855, rs12949956, rs2575876, rs9973159, rs4943289, rs1142, rs2268354, rs10781180, rs1605677, rs8056814, rs3138142, rs6899205, rs11080055, rs1064583, rs3760775, rs3825991, rs1926564, rs11142636, rs11884770, rs1378940, rs2842343, rs259842, rs11120691, rs2367070, rs2011092, rs7896471, rs17356664, rs17421410, rs16841920, rs1005819, rs2232613, rs17576

ADDITIONAL RESOURCES:
Age-related macular degeneration (Video)
Blindness and visual impairment

WEEKLY UPDATE: April 21, 2020


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