SUMMARY: Identification of genetic variants near the PDE4B gene that are associated with anxiety and stress disorders.
OVERVIEW: Anxiety disorders, where a person experiences excessive and inappropriate fear and anxiety, affect more than 20% of people at some point in their lives. Although stress-related disorders are a separate diagnosis, people often have both stress and anxiety disorders and the symptoms overlap. This study examined genetic data of over 12,000 Danish individuals diagnosed with various anxiety or stress-related disorders and over 19,000 controls. The genetic variants with the strongest association were found near the PDE4B gene, which is active in the brain and plays a role in helping nerve cells understand signals from hormones and neurotransmitters. The authors also report 9 additional genetic variants in other locations that are significantly associated with anxiety and stress disorders.
DID YOU KNOW? Some medications can increase symptoms of stress and anxiety disorders. This includes thyroid medications, asthma inhalers, and diet pills. [SOURCE]
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CONDITION-ASSOCIATED VARIANTS: rs7528604, rs1458103, rs113209956, rs6462203, rs6030245, rs11855560, rs2451828, rs16916239, rs79928194, rs342422
WEEKLY UPDATE: July 11, 2020