person pouring lotion on hand

Atopic dermatitis (Paternoster, 2015)

STUDY TITLE: Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

SUMMARY: Discovery of 10 new genomic regions associated with atopic dermatitis, also known as eczema.

OVERVIEW: The skin is the largest organ in the body, serving as a barrier to the outside world. The immune system helps support this barrier function, attacking “foreign” substances that come in contact with the skin. When this happens, the skin can become inflamed, red, and itchy. Atopic dermatitis (AD), also known as eczema, a skin inflammation is triggered by environmental factors that are actually not harmful to the body. Among many others, these factors can include temperature, soap, and clothing. AD is highly heritable, with genetics determining up to 90% of an individual’s susceptibility to the condition. To identify genetic variants that are associated with atopic dermatitis, this genome-wide association study examined over 116,000 individuals of European, African, Japanese, and Latino ancestries. The study found 21 regions of the genome associated with atopic dermatitis, 10 of which are novel. Altogether, these variants may explain around 15% of the variance in susceptibility to AD. The newly-identified genomic regions include genes involved in the immune system, particularly the function of T cells that play an important role in many autoimmune diseases.

DID YOU KNOW? Atopic dermatitis can be a persistent condition, with flare-ups occurring periodically. To help reduce the severity and frequency of symptoms, good skin care is critical. This includes regular application of a moisturizer, using a “scent-free” laundry detergent, and avoiding scratching of itching skin. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

atopic dermatitis sample results

AD-ASSOCIATED VARIANTS: rs61813875, rs10791824, rs12188917, rs6419573, rs2212434, rs4809219, rs2918307, rs2041733, rs12730935, rs2038255, rs7127307, rs7512552, rs6473227, rs6602364, rs4713555, rs10214237, rs10199605, rs4643526, rs12951971, rs7625909

ADDITIONAL RESOURCES:
Atopic dermatitis (Video)

WEEKLY UPDATE: April 28, 2020

Also, take a look at our Curology review!


Share this post
Share on facebook
Share on google
Share on twitter
Share on linkedin
Share on print
Share on email