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Bipolar Disorder (Mühleisen, 2014)

STUDY TITLE: Genome-wide association study reveals two new risk loci for bipolar disorder

SUMMARY: Bipolar disorder is linked to several genetic variants, some of which are in the ADCY2 gene.

DESCRIPTION: Bipolar disorder (aka manic-depressive illness) can cause abnormal shifts in mood, energy, and activity levels. Moods can range from periods of extremely “up” or energized behavior (called manic episodes) to extremely “down” or hopeless periods (called depressive episodes). This is likely a polygenic disease, meaning that it is probably caused by variants in many genes. This study examined 2.3 million genetic variants in 9,747 patients and 14,278 controls from Europe, Canada, and Australia in order to detect genetic variants that may be associated with the condition. In addition to confirming previously discovered variants, the study also identified variants in new genes that may play a role. One of these variants was in the ADCY2 gene. It encodes an enzyme that produces cAMP, a key signaling molecule in neuronal growth and many other processes.

DID YOU KNOW? If you have manic-depressive illness, it’s often helpful to have a daily schedule and routine that you stick to. Exercise, low levels of stress, and healthy eating can also help you manage your condition. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

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BIPOLAR DISORDER-ASSOCIATED VARIANTS: rs10994415, rs12290811, rs17826816, rs12202969, rs6550435

ADDITIONAL RESOURCES:
Overview of Bipolar Disorder
cAMP
Functional Roles for cAMP

WEEKLY UPDATE: July 23, 2019



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