SUMMARY: This study links several cell signaling pathways to the risk of developing hypertension.
DESCRIPTION: Hypertension, also called high blood pressure, is a major risk factor for many diseases, including heart disease and stroke. High blood pressure is thought to be highly heritable, but the genetic factors that influence the risk of hypertension are not well understood. This large meta-analysis included ~350,000 individuals and identified 31 novel genetic variants associated with hypertension. These variants help explain ~2% of the heritability of hypertension. Several variants were linked to the solute carrier transporter pathway, which is responsible for the transport of many molecules across cell membranes. Notch signaling and the RNA polymerase I promoter clearance pathway also had genetic variants associated with hypertension. Notch signaling plays a role in the division of neurons and is crucial to normal embryonic development. The RNA polymerase I promoter clearance pathway is involved in transcription, which is part of the process that produces proteins.
DID YOU KNOW? A healthy lifestyle can help reduce your risk of hypertension. Eating a healthy diet, exercising frequently, and limiting your alcohol consumption are all ways to prevent hypertension. [SOURCE]
SAMPLE RESULTS: Learn more about the Nebula Research Library.
BLOOD PRESSURE-ASSOCIATED VARIANTS: rs9349379, rs7406910, rs4387287, rs1008058, rs11229457, rs35529250, rs4728142
WEEKLY UPDATE: July 23, 2019