kidney

Chronic Kidney Disease (Chambers, 2010)

STUDY TITLE: Genetic loci influencing kidney function and chronic kidney disease in man

SUMMARY: Kidney disease is linked to genetic variants that influence serum creatinine and cystatin C – two of the main biomarkers of kidney function.

DESCRIPTION: Chronic kidney disease is a permanent loss of kidney function over time. This study examined the genomes of 23,812 people of European ancestry to identify genetic variants that are associated with an increased risk of this disease. It discovered 4 novel variants all linked to serum creatinine, a biomarker of kidney function. Creatinine is a waste product produced by our bodies during muscle metabolism. Normally, it is excreted; however, if your kidneys aren’t working well, creatinine can accumulate in your blood serum. A high serum creatinine level indicates that your kidneys aren’t functioning properly. The study also found that the same 4 variants were associated with cystatin C, a protein that serves as another biomarker of kidney function.

DID YOU KNOW? Keeping your blood sugar and blood pressure levels under control is the best way to prevent chronic kidney disease. Eating a low-salt, low-fat diet, exercising at least 30 minutes on most days of the week, and limiting alcohol are also good ways to prevent kidney disease. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Chronic kidney disease sample results.

KIDNEY DISEASE-ASSOCIATED VARIANTS: rs10206899, rs4805834, rs8068318, rs3127573

ADDITIONAL RESOURCES:
Overview of Chronic Kidney Disease
Creatinine Test
Cystatin C

WEEKLY UPDATE: July 23, 2019


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