Girl sleeping in bed insomnia

Insomnia (Lane, 2016)

STUDY TITLE: Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

SUMMARY: This study identified several genetic variants that were associated with insomnia, including 2 that were gender-specific.

DESCRIPTION:  Insomnia is a sleep disorder that makes it difficult to fall or stay asleep. This study examined genetic variants associated with chronic sleep disturbances, which affect 25-30% of adults worldwide. The study examined 503,325 people living in the United Kingdom in order to identify several genetic variants linked to insomnia, which explained roughly 21% of the heritability for insomnia symptoms. Interestingly, this study also found one variant (in the TGFBI gene) significantly associated with insomnia only in females and another (in the WDR27 gene) that was only significant in males. The TGFBI gene plays a key role in cell adhesion, while the exact function of the WDR27 gene is relatively unknown. However, it is thought to be involved in cell signaling and protein-protein interactions.

DID YOU KNOW? To try and prevent insomnia, you should avoid caffeine, alcohol, and heavy meals late in the day. Try to go to bed and get up at the same time each day. If you have trouble falling asleep, try relaxing before bed by reading a book, taking a bath, or making a to-do list if you’re worried about the things you need to do in the morning. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Insomnia sample results.

INSOMNIA-ASSOCIATED VARIANTS: rs113851554, rs5922858, rs145258459

ADDITIONAL RESOURCES:
An Overview of Insomnia
Cell Adhesion
Introduction to Cell Signaling

WEEKLY UPDATE: July 23, 2019

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