stones

Kidney Stones (Thorleifsson, 2009)

STUDY TITLE: Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density

SUMMARY: The risk of developing kidney stones is increased with a genetic variant in the CLDN14 gene.

DESCRIPTION: Kidney stone disease is a common condition in which hard deposits made of minerals and salts – usually calcium oxalate – build up. Few genetic variants that correlate to a person’s risk of developing this condition have been found. To discover such factors, this study examined 46,283 individuals from Iceland and the Netherlands. This study identified a genetic variant in the CLDN14 gene that appears to be correlated with an increased risk of developing this condition. This gene is expressed in the loop of Henle (part of the kidney, where water and salts are reabsorbed into the blood) and is thought to help with calcium transport. This variant was also associated with urine calcium levels and reduced bone mineral density.

DID YOU KNOW? Drinking plenty of water is one of the best ways to ensure you do not develop this kidney condition. Other preventative measures include reducing sodium and red meat in your diet and pairing calcium-rich foods with oxalate-rich foods (like spinach, peanuts, rhubarb, and chocolate). [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Kidney stones sample report.

KIDNEY STONES-ASSOCIATED VARIANTS: rs219779

ADDITIONAL RESOURCES:
Overview of Kidney Stones
Calcium Oxalate
Loop of Henle

WEEKLY UPDATE: July 23, 2019

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