SUMMARY: Susceptibility to melanoma is associated with variants in the ATM and CASP8 genes.
DESCRIPTION: Melanoma is a skin cancer that occurs when pigment-producing skin cells mutate and become cancerous. To identify genetic variants associated with the development of skin cancer, this study examined 11,389 individuals of European ancestry. The most significant variants were located in the ATM and CASP8 genes. The protein encoded by the ATM gene checks DNA for damage at various stages of the cell cycle and activates other genes if the DNA is damaged. The CASP8 gene plays an essential role in apoptosis. ATM and CASP8 have both been implicated in other types of cancers as well.
DID YOU KNOW? In order to prevent melanoma, you should wear sunscreen (at least 30 SPF) and protective clothing while also avoiding the midday sun and tanning beds. [SOURCE]
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MELANOMA-ASSOCIATED VARIANTS: rs258322, rs1393350, rs13016963, rs45430, rs1801516, rs7023329, rs401681
WEEKLY UPDATE: July 23, 2019