SUMMARY: Migraine without aura may be influenced by genetic variants that affect neuronal signaling, migration, and growth.
DESCRIPTION: Migraine without aura, also called the common migraine, is characterized by recurring, painful headaches. It does not have the early symptoms (aura) that other types of migraines have, such as dizziness, prickling skin, or weakness. They appear to be heritable, yet few genetic variants have been discovered. This study identified several genetic variants associated with this condition in 6,906 German and Dutch individuals, the most significant of which were in the MEF2D, PHACTR1, and ASTN2 genes, as well as one near the TGFBR2 gene. MEF2D is highly expressed in the brain and helps neurons form and send signals. PHACTR1 plays a role in synaptic activity (synapses allow neurons to pass signals to other cells). The product of the ASTN2 gene helps neurons move guided by glial cells, which are cells that surround neurons and provide support. Finally, the TGFBR2 gene regulates cell division and growth and has been previously reported as being linked with migraines.
DID YOU KNOW? Avoiding loud noises, bright lights, and stress, in addition to eating and sleeping on a regular schedule, may help prevent severe headaches. [SOURCE]
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MIGRAINE-ASSOCIATED VARIANTS: rs10166942, rs3790455, rs7640543, rs11172113, rs9349379, rs6478241
WEEKLY UPDATE: July 23, 2019