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Parkinson’s Disease (Nalls, 2019)

STUDY TITLE: Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-analysis of genome-wide association studies

SUMMARY: Identification of 90 genetic variants associated with Parkinson’s disease.

OVERVIEW:  Parkinson’s disease is a neurodegenerative disorder caused by reduced dopamine signaling in some regions of the brain that leads to tremors. This can impair various activities that involve muscle movements including walking, speaking and eating. To date, Parkinson’s disease remains largely a genetic mystery. To advance our understanding of genetic risk factors for Parkinson’s, this study analyzed the genomes of almost 1.5 million individuals of European ancestry and identified 90 genetic variants, of which 38 were novel. Many variants were in genes that are active in regions of the brain involved in movement control. The study also identified genetic associations between Parkinson’s and smoking as well as Parkinson’s and educational attainment.

DID YOU KNOW? Diets rich in antioxidants, omega-3 fatty acids and vitamin D3 and CoQ10 are believed to reduce the risk of Parkinson’s disease. Reducing stress and exercising may also help. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

PARKINSON’S-ASSOCIATED VARIANTS: rs356182, rs356203, rs34637584, rs35749011, rs34311866, rs62053943, rs199453, rs356228, rs7225002, rs1474055, rs7221167, rs10847864, rs5019538, rs10513789, rs823118, rs76904798, rs4698412, rs117896735, rs112485576, rs17686238, rs199351, rs1867598, rs12456492, rs76763715, rs11557080, rs35643925, rs873786, rs6854006, rs117073808, rs11150601, rs3802920, rs4101061, rs2251086, rs13294100, rs10756907, rs10797576, rs11158026, rs1293298, rs117615688, rs4653767, rs620513, rs57891859, rs141128804, rs9912362, rs896435, rs73038319, rs11683001, rs13117519, rs3104783, rs4140646, rs6658353, rs138017112, rs6808178, rs55961674, rs850738, rs72840788, rs2248244, rs6497339, rs9267659, rs979812, rs181609621, rs2295545, rs75859381, rs10221156, rs11707416, rs12497850, rs12528068, rs11610045, rs144755950, rs62333164, rs12283611, rs34025766, rs55818311, rs1450522, rs2269906, rs2904880, rs61169879, rs10748818, rs6825004, rs12951632, rs4771268, rs26431, rs6500328, rs997368, rs3742785, rs7938782, rs666463, rs114138760, rs11578699, rs6476434, rs11950533, rs77351827, rs12600861, rs6875262, rs9568188, rs2280104, rs76116224, rs2042477, rs8087969, rs76949143, rs4954162, rs9261484, rs1941685, rs2086641, rs11658976, rs12147950, rs7134559

Parkinson’s disease
The role of dopamine

WEEKLY UPDATE: November 16, 2019

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