SUMMARY: Identification of novel genetic variants associated with personality traits as well as a genetic correlation between personality and predisposition to psychiatric disorders.
DESCRIPTION: Personality is determined by environmental and genetic factors. It can be modeled according to five broad domains (“Big Five”): extraversion, neuroticism, agreeableness, conscientiousness, and openness.This study identified five new genetic variants associated with the Big Five by examining genetic data of over 200,000 individuals of European ancestry. Additionally, this study has discovered that the genetic factors that determine this trait also influence the risk of psychiatric disorders. For example, openness was shown to be genetically correlated with bipolar disorder and schizophrenia. High neuroticism and extraversion were genetically correlated with ADHD as well as depression and anxiety. Low agreeableness was associated with narcissism and psychopathy.
DID YOU KNOW? The “Big Five” personality traits are often used by employers to hire employees. For most professions, conscientiousness – which involves being responsible and reliable – was the most highly valued trait. [SOURCE]
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PERSONALITY-ASSOCIATED VARIANTS: rs1426371, rs6481128, rs57590327, rs2164273
The Big Five
WEEKLY UPDATE: August 16, 2019