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Primary Biliary Cirrhosis (Mells, 2011)

STUDY TITLE: Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

SUMMARY: Genetic variants linked to pathways that promote inflammation may play a role in the development of primary biliary cirrhosis.

DESCRIPTION: Primary biliary cirrhosis is a chronic, autoimmune liver disease. Autoimmune diseases are characterized by the immune system mistakenly attacking the body’s own cells. For this condition, this eventually results in the destruction of your bile ducts, where bile is produced. Bile helps in processes like digestion and the elimination of toxins from the body. This study linked genetic variants in the HLA genes to this liver disease in 7,003 individuals of British or Irish ancestry. HLA genes encode for major histocompatibility complex (MHC) proteins that help recognize foreign molecules and elicit an immune response. Other genetic variants identified in this study provide additional evidence for the role of other immune system pathways in primary biliary cirrhosis. 

DID YOU KNOW? Reducing or eliminating alcohol, eating a healthy diet, and getting regular exercise are all ways to try and prevent liver damage and development of primary biliary cirrhosis. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Primary biliary cirrhosis sample results.

PRIMARY BILIARY CIRRHOSIS-ASSOCIATED VARIANTS: rs7774434, rs17129789, rs10931468, rs12531711, rs485499, rs12134279, rs3745516, rs6421571, rs12924729, rs7665090, rs860413, rs911263, rs2293370, rs11117432, rs968451, rs1800693, rs6974491

ADDITIONAL RESOURCES:
Primary Biliary Cirrhosis
HLA Genes

WEEKLY UPDATE: July 23, 2019



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