Hands outstretched, skin

Psoriasis (Tsoi, 2015)

STUDY TITLE: Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

SUMMARY: Genetic variants linked to the immune system are associated with psoriasis.

DESCRIPTION:  Psoriasis is a condition where extra skin cells build-up on the surface of the skin, causing scales and itchy red patches to form. In an effort to better understand genetic variants that lead to an increased risk of developing this condition, this study examined 10,740 individuals of European ancestry. This study identified 6 genetic variants that may increase the risk of psoriasis. None of these variants were in protein coding regions: 3 were intronic and 3 were intergenic. An intron is a DNA sequence that interrupts genes and is not used to produce proteins. An intergenic region is exactly what the name suggests – a stretch of DNA sequences between genes. Most of the variants were near genes that are involved in the immune system and inflammation, suggesting that these variants may play a role in regulating these processes.

DID YOU KNOW? Using moisturizing lotions, avoiding dry or cold weather, and using a humidifier in your house may help prevent psoriasis flare-ups from occurring. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Psoriasis sample report.

PSORIASIS-ASSOCIATED VARIANTS: rs7637230, rs2675662, rs4685408, rs114934997, rs10789285, rs35343117

ADDITIONAL RESOURCES:
Psoriasis Overview
Intron
Intergenic

WEEKLY UPDATE: July 23, 2019

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