SUMMARY: Identification of 4 genetic variants associated with psychotic experiences.
DESCRIPTION: Psychosis, or psychotic experiences, typically describes a condition where an individual has an impaired relationship with reality. The most common experiences include hallucinations and delusions. Though these psychotic experiences can occur alongside trauma, stress, or substance abuse, they can also be a symptom of an underlying psychiatric illness. To better understand the genetic causes of psychosis and their connection to psychiatric illnesses, this study analyzed the genetic data of 127,966 individuals of European ancestry who self-reported their psychotic experiences. The 4 discovered variants indicated connections between psychotic experiences and major depressive disorder, autism spectrum disorder, ADHD, as well as schizophrenia. Collectively, these variants explained nearly 2% of the heritability of psychotic experiences, indicating other rare variants may help better explain the condition.
DID YOU KNOW? Some forms of therapy, such as cognitive behavior therapy, have proven to be effective in helping people who experience psychotic episodes manage their condition. [SOURCE]
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PSYCHOSIS-ASSOCIATED VARIANTS: rs10994278, rs549656827, rs75459873, rs3849810
WEEKLY UPDATE: October 6, 2019