SUMMARY: This study identified eight new loci associated with re-experiencing post-traumatic stress disorder (PTSD) trauma.
DESCRIPTION: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can occur when individuals experience or witness a traumatic event such as a natural disaster, a serious accident, or violence. Re-experiencing the trauma is the most characteristic symptom of PTSD. While many factors influence the development of PTSD, genetic variants may lead to an increased predisposition of developing the disorder. To identify possible genetic risk factors for re-experiencing a trauma, this genome-wide association study examined 164,643 African American and European American veterans. Eight variants were found to be linked to re-experiencing PTSD trauma, explaining less than 1\u0025 of the heritability. Regions near the CAMKV, KANSL1, and TCF4 genes were particularly significant. CAMKV was previously associated with educational attainment and TCF4 is known to be associated with schizophrenia.
DID YOU KNOW? There are various psychiatric therapies that can help treat PTSD. Most therapies require the patient to confront and discuss the trauma. Medications such as antidepressants are prescribed as well. [SOURCE]
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PTSD-ASSOCIATED VARIANTS: rs2777888, rs2123392, rs2532252, rs7519147, rs10235664, rs4697248, rs7688962, rs67529088
Symptoms of PTSD
WEEKLY UPDATE: August 9, 2019