SUMMARY: Development of a polygenic risk score for thyroid cancer based on 10 previously identified genetic variants.
OVERVIEW: The thyroid is a butterfly-shaped gland in the front of the neck that produces hormones which control important bodily functions like blood pressure, temperature, and heart rate. Cancer of the thyroid is more heritable than most other cancer types, and it affects over 50,000 individuals each year in the United States. This study developed a polygenic score based on 10 previously identified genetic variants to predict the risk of papillary thyroid cancer, the most common type of the disease. The researchers found that the score explained roughly 8% of the heritability of the cancer in their study group. The prediction became more accurate when the polygenic score was used together with clinical factors to predict risk of the cancer. The study also showed that individuals in the 90th percentile had roughly a 7-times greater risk of this cancer compared to the individuals in the 10th percentile.
DID YOU KNOW? Despite being a highly heritable disease, radiation exposure, obesity, and consuming a diet high in iodine may all increase the risk of developing papillary thyroid cancer. [SOURCE]
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ASSOCIATED VARIANTS: rs12129938, rs11693806, rs6793295, rs73227498, rs2466076, rs1588635, rs7902587, rs368187, rs116909374, rs2289261
WEEKLY UPDATE: March 16, 2020