SUMMARY: Resistance to tuberculosis may be associated with a genetic variant in the WT1 gene.
DESCRIPTION: Tuberculosis is a disease caused by bacteria that usually affect the lungs, although it can also damage other parts of the body. Common symptoms of this condition include coughing up blood, fatigue, and pain in the chest. While it is known some people are resistant to tuberculosis, the genetic variants that may lead to this trait have not been discovered. This study identified a novel genetic variant associated with resistance. It was discovered in a Ghanaian population of 3,176 individuals and the protective effect was then confirmed for Gambian, Indonesian, and Russian populations. The variant is near WT1, a gene that is involved in the development and function of the kidneys.
DID YOU KNOW? The most important part in preventing the spread of tuberculosis is stopping the transmission of the disease. Getting vaccinated, identifying and curing people with the disease, and coughing into your arm or tissue can help stop the spread of the disease. [SOURCE]
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TUBERCULOSIS-ASSOCIATED VARIANTS: rs2057178
WEEKLY UPDATE: July 23, 2019