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Glaucoma (Craig, 2020)

WEEKLY UPDATE: January 31, 2020

STUDY TITLE: Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

SUMMARY: Identification of over 100 genetic variants associated with glaucoma.

OVERVIEW:  Glaucoma is a medical condition characterized by damage to the eye’s optic nerve usually due to increased pressure in the eye. Because no cost-effective way to screen for glaucoma currently exists, researchers explored the use of polygenic risk scores to determine an individual’s risk. This study utilized data from over 120,000 individuals of European ancestry to find genomic regions associated with glaucoma. The researchers identified 114 genetic variants associated with glaucoma, many of which are novel. The polygenic risk scores calculated using these variants indicated a 15-fold higher risk of advanced glaucoma for individuals in the 90th percentile of polygenic scores.

DID YOU KNOW? The best way to prevent the development of glaucoma is to schedule regular eye exams with your doctor. [SOURCE]

SAMPLE RESULTS:

ANALYZED VARIANTS: rs10918274, rs2472493, rs9913911, rs59454355, rs28795989, rs2275241, rs9853115, rs944801, rs6838291, rs2745572, rs2022945, rs1579050, rs57111852, rs58073046, rs6914444, rs56319620, rs4821712, rs2896175, rs76325372, rs35155027, rs9494457, rs7924522, rs1867409, rs11234741, rs2439042, rs4102217, rs8064739, rs738722, rs4141194, rs2188836, rs75265191, rs327712, rs2935072, rs6140009, rs9608740, rs12216891, rs17339357, rs7089636, rs4658101, rs8009633, rs2249195, rs66500121, rs2274224, rs73111535, rs3785856, rs12068500, rs62580791, rs9544024, rs12139208, rs324762, rs6741499, rs6732795, rs73148965, rs113542380, rs72669675, rs722585, rs2145826, rs34952318, rs1283696, rs10869665, rs9816799, rs1286771, rs4703855, rs74984957, rs13009933, rs2526101, rs73294447, rs11859314, rs4601984, rs4434990, rs440677, rs4420855, rs74259971, rs3743861, rs11229165, rs12045227, rs56152426, rs7273775, rs4412362, rs6065171, rs2526385, rs4709210, rs4128399, rs4936100, rs2881425, rs73220190, rs1084524, rs62188040, rs11710845, rs1362227, rs447324, rs756481, rs351973, rs36006455, rs3184504, rs163524, rs12280392, rs11008626, rs12913832, rs56405342, rs893830, rs10435033, rs12778014, rs10796912, rs1126809, rs7799028, rs9530143, rs11567976, rs274760, rs1563966, rs62172701, rs1347141, rs1616405, rs61755579

ADDITIONAL RESOURCES:
Glaucoma
What Happens Inside Eyes with Glaucoma? (Video)

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