illustration of pink heart

HDL cholesterol level (Richardson, 2020)

STUDY TITLE: Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

SUMMARY: Identification of 534 genetic variants associated with the HDL cholesterol level in the blood and analysis of its contribution to the risk of coronary heart disease.

DESCRIPTION: Coronary heart disease (CHD) is a condition that develops when the heart’s arteries cannot supply enough oxygen to the heart muscle. Coronary heart disease is the leading cause of death in the United States. It occurs when plaque builds up in the heart’s arteries and blocks the blood flow to the heart. Arterial plaque consists of multiple substances that circulate in the blood. One of the substances that the study examined is HDL (high-density lipoprotein) cholesterol, also known as the “good” cholesterol. To this end, this study analyzed genetic data of over 440,000 individuals of European descent to identify genomic regions associated with HDL cholesterol levels in the blood. The researchers identified 534 genetic variants, including 383 novel variants, associated with HDL cholesterol levels. The analysis showed that a high HDL cholesterol level is associated with a decreased risk of coronary heart disease. However, this association weakened when the researchers considered all fats and proteins in the study. The study results still suggest that HDL cholesterol plays an important role in the development of heart disease.

DID YOU KNOW? HDL cholesterol is often called the “good” cholesterol because it helps your body remove other types of cholesterol from the bloodstream. Some ways to boost HDL cholesterol levels include exercise and a diet low in trans fats. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Sample results for HDL cholesterol level

HDL CHOLESTEROL LEVEL-ASSOCIATED VARIANTS: rs9989419, rs1800588, rs1601934, rs343, rs964184, rs77960347, rs8086351, rs79600951, rs2740488, rs72836561, rs2281718, rs116843064, rs429358, rs174566, rs9987289, rs80005209, rs6073958, rs1800961, rs676210, rs11789603, rs13107325, rs1052373, rs2943645, rs10162642, rs12976395, rs921919, rs141469619, rs55781197, rs3768321, rs308, rs571848809, rs367070, rs686030, rs2925979, rs4871603, rs998584, rs75609851, rs737338, rs1054852, rs2792751, rs6469605, rs2066714, rs113740515, rs545858676, rs78058190, rs145276599, rs35493868, rs4731701, rs4969141, rs7136506, rs11658786, rs150844304, rs12422125, rs12224170, rs140584594, rs11228871, rs13389219, rs11228212, rs3184504, rs17138358, rs61352607, rs2263329, rs7817574, rs2256609, rs559355, rs2642438, rs6902116, rs58473820, rs193084249, rs2498786, rs11239536, rs79153732, rs61805075, rs116978226, rs12740374, rs3936511, rs7308864, rs56271783, rs144311893, rs13235365, rs11045171, rs6765484, rs771481, rs75662196, rs9647335, rs112001035, rs11967891, rs4273010, rs62102718, rs35137994, rs12411732, rs75152587, rs4239651, rs10513801, rs2298624, rs11664369, rs133015, rs72959041, rs10233430, rs2297402, rs6824451, rs61435086, rs72823020, rs12928099, rs1043897, rs1047964, rs3775228, rs11066320, rs2523978, rs17326656, rs2068888, rs77403571, rs632057, rs6542680, rs72647336, rs62271373, rs73243877, rs72926946, rs11645157, rs9817452, rs2159607, rs142288236, rs2307111, rs10955991, rs4871624, rs7750688, rs7757193, rs142493909, rs907866, rs4650994, rs7925100, rs532436, rs267738, rs17309930, rs3129797, rs235314, rs1047891, rs3803501, rs7170463, rs13379043, rs8081548, rs117687565, rs142965311, rs10750766, rs12485478, rs3736802, rs6499102, rs1534696, rs2963468, rs55935382, rs12510382, rs1468642, rs112771035, rs3129962, rs11605837, rs10774579, rs4686739, rs2435307, rs74419430, rs11880219, rs6934962, rs2247355, rs4930352, rs66763009, rs1132274, rs10774439, rs34138141, rs62492368, rs10786114, rs11640494, rs9622830, rs703966, rs2289863, rs74735576, rs3814883, rs557933, rs11658872, rs10846690, rs16928809, rs2804894, rs35777071, rs13097947, rs34675318, rs141062196, rs8014289, rs10504477, rs1168114, rs3763236, rs830620, rs3732356, rs2862954, rs12650112, rs1446585, rs11118320, rs9608972, rs12150914, rs11075985, rs9604045, rs1045241, rs13076933, rs2723065, rs9274346, rs11231138, rs2268840, rs59104589, rs4356188, rs13220570, rs77631377, rs595767, rs77605964, rs3749748, rs41292412, rs116006942, rs367677, rs143474489, rs6457807, rs2298632, rs9657541, rs117230571, rs13269725, rs4979372, rs62112763, rs577525, rs1055582, rs2314338, rs3747973, rs78025076, rs6123685, rs9646167, rs4760, rs28876383, rs2011614, rs1611719, rs10761737, rs7595075, rs7158166, rs4788446, rs138354839, rs28362901, rs144033177, rs2218793, rs7769059, rs4599108, rs587739738, rs62491176, rs2237035, rs968050, rs11057468, rs140201358, rs4800356, rs75817747, rs76428106, rs11170516, rs6924387, rs74456742, rs10252234, rs6664374, rs13147189, rs62486442, rs9347737, rs147525635, rs62338910, rs140064750, rs2071379, rs76602912, rs34555420, rs1225053, rs75572195, rs113710278, rs150237291, rs34940374, rs76213248, rs2964007, rs2520096, rs35706812, rs73221948, rs9469583, rs6590207, rs11601507, rs12803463, rs79634051, rs13263821, rs2705616, rs9980311, rs330042, rs11021232, rs11631178, rs12411959, rs1884589, rs113761591, rs12814794, rs2585398, rs374039502, rs72729582, rs2910949, rs67344323, rs2204886, rs74500135, rs11688682, rs16969990, rs11687520, rs1663626, rs13066793, rs62092069, rs13144151, rs838777, rs3733890, rs34695471, rs55652051, rs17740942, rs28712486, rs11254464, rs13042367, rs12045101, rs12975319, rs1771582, rs7583067, rs2781668, rs73457437, rs11878235, rs73082723, rs150300171, rs12516070, rs32578, rs62428831, rs72801474, rs12686780, rs4875043, rs10950390, rs61884030, rs2298214, rs15052, rs68006638, rs9884482, rs13323506, rs183078, rs4654395, rs78595810, rs17041868, rs61926301, rs185073199, rs7036107, rs72654647, rs112192770, rs200540247, rs248653, rs1240820, rs56105022, rs1086056, rs4078216, rs55801554, rs9877304, rs11043221, rs17566828, rs2417125, rs11883967, rs4947121, rs738409, rs10896581, rs183906992, rs2965169, rs11961755, rs62565259, rs2098918, rs77234291, rs1252425, rs77916918, rs7488780, rs72805692, rs2551980, rs4976033, rs61919816, rs6021914, rs73179655, rs113261881, rs28510484, rs74328314, rs12998038, rs57074291, rs10916239, rs1970811, rs75032664, rs7725218, rs6790951, rs8126001, rs13041173, rs3794752, rs1818917, rs11878604, rs1431659, rs72755439, rs13111599, rs2364723, rs7622114, rs7658082, rs9646934, rs254559, rs12921195, rs1412234, rs34717889, rs61596977, rs1083470, rs11171710, rs73151974, rs76530346, rs58298943, rs9526023, rs17124112, rs115912456, rs7251640, rs10438354, rs3825669, rs16975758, rs6940493, rs34720381, rs1894544, rs549058, rs8127283, rs75246752, rs34830321, rs1349852, rs10826337, rs7903537, rs1155347, rs117499775, rs2100692, rs4691379, rs11938781, rs1862205, rs141440048, rs2339234, rs57348955, rs6806529, rs12926854, rs567056, rs76246107, rs4855582, rs56017932, rs2245477, rs2645979, rs79311290, rs11653260, rs2534596, rs6874833, rs6131012, rs7650845, rs6059958, rs3859588, rs6987377, rs75479205, rs11009262, rs1395221, rs201441, rs6738438, rs7316878, rs12146566, rs13300004, rs2362541, rs35580606, rs6762415, rs7826177, rs12692596, rs42125, rs6002946, rs680321, rs2750411, rs38166, rs4755720, rs8102873, rs10879184, rs11000468, rs11948445, rs139828053, rs2456722, rs35828909, rs36092527, rs10901802, rs34559316, rs61905599, rs7039168, rs1411432, rs7218647, rs9610329, rs16885512, rs2175766, rs13195251, rs28455602, rs3746915, rs4410790, rs56131490, rs61748951, rs12713007, rs4550673, rs514924, rs79616633, rs4997370, rs1955512, rs4924471, rs12705595, rs6893139, rs144567740, rs2414178, rs11202156, rs1517500, rs17185038, rs2302367, rs11546878, rs1012306, rs2663924, rs3903399, rs61993685, rs117435644, rs7188071, rs2155220, rs12119128, rs11622947, rs502627, rs78456138, rs546436456, rs73455693, rs12986742, rs67934334, rs454968, rs1760940, rs59737437, rs880674, rs1567353, rs445841, rs550916783, rs138026745, rs4233367, rs407133, rs254024, rs118128493

ADDITIONAL RESOURCES:
Coronary Heart Disease (Video)
Coronary Heart Disease
LDL and HDL Cholesterol: “Bad” and “Good” Cholesterol

WEEKLY UPDATE: April 5, 2020







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