We are excited to announce the launch of the Nebula Research Library – a weekly updated collection of curated genomic research studies. With the Nebula Research Library, you will be able to stay up to date with the latest discoveries in human genomics and how they may relate to you. The library includes genome-wide association studies as well as research articles about the oral microbiome.
In this blog post, we’ll explain how to use the Nebula Research Library and understand the results of the genome-wide association studies that it contains. We also explain how to read oral microbiome results in a separate blog post
Figure 1 shows an exemplary library entry – a genome-wide association study that examined the genetics of restless leg syndrome. First, you are presented with the title of a research article, along with publication date, lead author and name and publication journal (Figure 1A). To the right of the article title, you can find a share button that you can use to share your results over email or on social media and below there are topic tags that will help you explore the Nebula Research Library for related content.
Next, we provide a summary of the study along with some additional information that is relevant to the condition studied (Figure 1B). In the study example below we explain what restless legs syndrome is, provide some information about how the study was conducted, and explain the function of the genes in which restless legs syndrome-associated variants have been discovered.
We then present a list of 5 novel and/or most significant variants that have been associated with restless leg syndrome in this study (Figure 1C). The second part of the table contains your personal genetic information, called your genotype (Figure 1D). Here you can see whether the genetic variants that have been identified in the study are likely to be present in your genome. We also provide an estimated accuracy of the results. While the average accuracy of our low-coverage whole-genome sequencing is ~ 99%, it can be considerably lower for some variants. This is the case for rare variants or if the genomic region around a variant was not well sequenced. In the near future, we will start offering the option to purchase high-coverage whole-genome sequencing which will enable us to provide more accurate results and additional reports.
Finally, we provide a list of other significant genetic variants that have been identified in the study as well as links to other websites with additional information about study-related topics (Figure 1E).
We are launching the Nebula Research Library containing over 50 articles. Every week we will be adding more content based on the newest discoveries as well as important studies from the past decades of genomics research. The Nebula Research Library will quickly grow to hundreds of articles. To facilitate exploration and discovery we added tagging functionality, whereby every study in the library is tagged with one or more terms that add some context (Figure 1A, Figure 2).
While you explore the Nebula Research Library please keep in mind that it should be used for informational and educational purposes only. If a study indicates that a specific variant that may be present in your genome is associated with a certain condition, this does not mean that you either have or will develop this condition. We do not provide any medical advice, and the library is not intended to be used for any diagnostic purpose. Please always seek the assistance of a health care provider with any questions regarding your health.