The chemical structure of chlesterole resembles steroid hormones, bile acid and vitamin D because it is used for their biosynthesis.

LDL cholesterol level (Richardson, 2020)

STUDY TITLE: Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

SUMMARY: Identification of 220 genetic variants associated with the LDL cholesterol level in blood and analysis of its contribution to the risk of coronary heart disease.

DESCRIPTION: Coronary heart disease (CHD) is a condition that develops when the heart’s arteries cannot supply enough oxygen to the heart muscle. Coronary heart disease is the leading cause of death in the United States. It occurs when plaque builds up in the heart’s arteries and blocks the blood flow to the heart. Arterial plaque consists of multiple substances that circulate in the blood. One of the substances that the study examined is LDL (low-density lipoprotein) cholesterol, also known as the “bad” cholesterol. To this end, this study analyzed genetic data of over 440,000 individuals of European descent to identify genomic regions associated with LDL cholesterol levels in the blood. The researchers identified 220 genetic variants, including 123 novel variants, associated with LDL cholesterol levels. The analysis showed that a high LDL cholesterol level is associated with an increased risk of coronary heart disease. However, this association weakened when the researchers considered all fats and proteins in the study. However, the results still suggest that LDL cholesterol plays an important role as a risk factor for heart disease.

DID YOU KNOW? Coronary heart disease develops over many decades. A healthy lifestyle can significantly decrease the risk of developing coronary heart disease. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Sample results for LDL cholesterol level

LDL CHOLESTEROL LEVEL-ASSOCIATED VARIANTS: rs836550, rs4620259, rs146433259, rs72774870, rs77257036, rs8008068, rs144984216, rs6714750, rs61433703, rs79828839, rs56208742, rs12936113, rs990619, rs7108486, rs28406917, rs77013160, rs73075609, rs7090758, rs62011285, rs72638977, rs28768427, rs1007938, rs869412, rs7241918, rs61754230, rs112403212, rs9686661, rs913499, rs204469, rs6560499, rs12445804, rs56236159, rs1250258, rs2256814, rs4148826, rs10851478, rs11227247, rs35882350, rs111338114, rs12162782, rs10910476, rs438568, rs11014204, rs576573069, rs12471768, rs61778883, rs72733928, rs61988556, rs6050463, rs56212732, rs112758337, rs9894946, rs551473284, rs115739682, rs960596, rs9471975, rs12197047, rs191064657, rs12078100, rs73025516, rs59328596, rs2021092, rs4808360, rs11568318, rs1731243, rs6589939, rs541155877, rs34568880, rs13107325, rs3932048, rs140584594, rs55921103, rs6573971, rs2718717, rs28631087, rs11206788, rs56113850, rs549956721, rs1350559, rs9841897, rs17476364, rs4818025, rs6667939, rs115458560, rs1016988, rs6090101, rs3780181, rs6073958, rs67050321, rs9832727, rs9491699, rs2066714, rs10448340, rs62033400, rs112987086, rs7776054, rs880315, rs4954192, rs72823020, rs62120394, rs3732359, rs1495741, rs145730801, rs3110609, rs74869459, rs13283282, rs12990177, rs704, rs117139027, rs11786083, rs9496567, rs10832963, rs10231941, rs9298506, rs11789603, rs2925677, rs146534110, rs12246352, rs71311871, rs1556562, rs12603885, rs9929977, rs77960347, rs4782568, rs2250802, rs2238162, rs11601507, rs1532085, rs114165349, rs1458038, rs8101801, rs224424, rs13108218, rs1229984, rs62118464, rs2160994, rs907866, rs3822855, rs76967117, rs4722551, rs28849176, rs7569317, rs261334, rs12948394, rs13076933, rs233721, rs2737265, rs113177823, rs9834932, rs7734476, rs116734477, rs7562734, rs3179865, rs9391803, rs11621792, rs2068888, rs72631343, rs76079263, rs6093446, rs6602912, rs17050272, rs6475606, rs1800961, rs55714927, rs2287622, rs150474434, rs9884390, rs1801689, rs7202323, rs7746081, rs2740488, rs117733303, rs1169294, rs35081008, rs2642438, rs2618566, rs150262789, rs11206517, rs62116889, rs61775180, rs9987289, rs36043200, rs188247550, rs597808, rs56130071, rs6709904, rs6693893, rs2073547, rs59379014, rs12208357, rs34392107, rs4738684, rs516316, rs174564, rs79220007, rs3764261, rs6874202, rs1260326, rs1883711, rs556107, rs1168127, rs34042070, rs77542162, rs964184, rs472495, rs2738447, rs115478735, rs118039278, rs430096, rs4299376, rs8107974, rs28601761, rs12916, rs934197, rs4970834, rs4452060, rs11591147, rs1551891, rs143020224, rs6857

ADDITIONAL RESOURCES:
Coronary Heart Disease (Video)
Coronary Heart Disease
LDL and HDL Cholesterol: “Bad” and “Good” Cholesterol

WEEKLY UPDATE: April 5, 2020







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