Lupus (Chen, 2020)

WEEKLY UPDATE: March 2, 2020

STUDY TITLE: Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

SUMMARY: Development of a genetic risk score to predict the risk of systemic lupus erythematosus (SLE).

OVERVIEW:  Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by widespread inflammation and tissue damage. More than 200,000 new SLE cases are diagnosed in the United States every year. About one half of SLE patients experience kidney disease, which is the one of the most common causes of death in SLE patients. In this study, researchers created a genetic risk score (GRS) for SLE using previously published genetic variants significantly associated with SLE in European and Chinese patients.

DID YOU KNOW? Women are nine times more likely to develop lupus than men. This is because in addition to genetic factors, environmental factors likely play a role in the development of lupus. [SOURCE]

SAMPLE RESULTS:

ANALYZED VARIANTS: rs2187668, rs11889341, rs17849502, rs2070197, rs34572943, rs4728142, rs36014129, rs7708392, rs6932056, rs2736340, rs2431697, rs7444, rs2476601, rs2304256, rs2205960, rs6568431, rs1801274, rs7726414, rs10028805, rs2732552, rs1418190, rs12802200, rs9267992, rs6740462, rs3768792, rs10774625, rs9652601, rs2280381, rs564799, rs7941765, rs4948496, rs1059312, rs2941509, rs6445972, rs2327832, rs2111485, rs3093030, rs223881, rs2934498

ADDITIONAL RESOURCES:
Systemic lupus erythematosus
Systemic lupus erythematosus (Video)
Autoimmune disorders

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