GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
This study identified novel genetic variants associated with non-alcoholic fatty liver disease (NAFLD).
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease affecting around 17-30% of the Western population. It is characterized by fat deposits in the liver of individuals who consume little or no alcohol. Fat deposits in the liver can cause inflammation, scarring, and liver failure. This study examined 9,677 participants of European ancestry to determine genetic variants that are associated with NAFLD. Several of the discovered variants were also linked to other diseases such as gout and liver fibrosis. Other variants were associated with increased levels of liver enzymes in the blood that indicate liver disease or injury.
Did you know?
Eating a healthy diet, limiting your portion sizes, and maintaining a healthy weight are proven to decrease the risk of NAFLD. (Source)
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