model of the human brain

Neuroticism (Luciano, 2017)

WEEKLY UPDATE: October 24, 2019

STUDY TITLE: Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

SUMMARY: Identification of 116 genetic variants associated with neuroticism.

DESCRIPTION:  Neuroticism is a personality trait characterized by negative emotionality (e.g. anger, guilt, anxiety) and associated with poorer mental and physical health. Though heritability may account for up to 50% of an individual’s likelihood of having neuroticisim, most genetic factors remains unknown. This genome-wide association study analyzed the genomes of almost 330,000 individuals of European ancestry and discovered 116 genetic variants that were found to be associated with neuroticism. Together, these variants explain about 3% of an individual’s likelihood of developing the disorder. Some of these variants are near or within genes associated with cell metabolism, as well as genes previously linked to major depression disorder and anxiety.

DID YOU KNOW? Being mindful of your feelings and creating positive experiences may help overcome neuroticism. [SOURCE]


“The Big Five” Personality Traits

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