Гистерезис роговицы (Симко, 2020)

ТИТУЛЬНЫЙ ТИТУЛ: Общегеномное исследование биомеханических свойств роговицы идентифицирует более 200 локусов, давая представление о генетической этиологии глазных заболеваний.

РЕЗЮМЕ: Identification of 203 generic variants associated with corneal hysteresis, a measure of the “shock-absorbing” ability of the cornea.

ОБЗОР: The cornea is a dome-shaped “window” covering the front part of the eye. It serves to both protect the eye and focus light to help us see. Damage to the cornea can be detrimental to eyesight, so doctors commonly use a number of metrics to measure the cornea’s health. One metric is corneal hysteresis, which is a measure of the “shock-absorbing” ability of the cornea. Decreased corneal hysteresis has previously been connected to glaucoma and other disorders of the eye. This genome-wide association study of over 100,000 individuals of European ancestry sought to identify variants associated with corneal hysteresis. The study found 203 genetic variants nearly all of which are newly-discovered. Some of the identified variants are near genes that play a role in the production of collagen, a substance that provides structure to the eyes and many other tissues in the body.

ТЫ ЗНАЛ? Corneal transplants are the most common type of transplant surgeries, with nearly 50,000 performed each year. [ИСТРАХ]

РЕЗУЛЬТАТЫ ОБРАЗЦА: Узнайте больше о Научно-исследовательская библиотека по туманности.

corneal hysteresis sample results


HYSTERESIS-ASSOCIATED VARIANTS: rs1044864, rs142493024, rs28526212, rs7635832, rs34944131, rs11659764, rs2755238, rs77542162, rs150202082, rs27323, rs121908120, rs72755233, rs1200105, rs139498917, rs12493217, rs6792542, rs72620820, rs6415788, rs238237, rs8070232, rs7019538, rs7863424, rs2645773, rs56009602, rs12913547, rs11786592, rs12476069, rs2393728, rs9853115, rs62014490, rs7518099, rs2879813, rs1042917, rs4656744, rs17512836, rs55923934, rs2745951, rs10817467, rs9038, rs2980046, rs11917483, rs11712833, rs7025044, rs13108668, rs11594610, rs717605, rs34552401, rs256869, rs13167730, rs1344672, rs4641686, rs187977459, rs1746486, rs2875238, rs9510275, rs2109019, rs12939159, rs17665178, rs11077857, rs11869086, rs8079290, rs10742752, rs12594979, rs28667150, rs786914, rs66560819, rs4363451, rs3118519, rs7952095, rs6816503, rs4008768, rs10788639, rs2468506, rs34372952, rs6567331, rs7919525, rs12498681, rs4561781, rs10139614, rs12526513, rs11142375, rs663044, rs2950790, rs7585194, rs6874844, rs6137178, rs1544557, rs34869, rs11923081, rs144596877, rs7651617, rs60581858, rs4643535, rs61814077, rs144403225, rs11156962, rs78036526, rs1755056, rs12193050, rs4938174, rs4374230, rs6709656, rs1772570, rs141621919, rs7301793, rs2035835, rs56042419, rs2286936, rs3890958, rs12760453, rs72828345, rs75529319, rs78625510, rs10838709, rs116072427, rs4948546, rs10151339, rs236940, rs58671886, rs12196123, rs1360485, rs851615, rs10758441, rs4848406, rs573455, rs3782473, rs1573019, rs3004212, rs3819504, rs712097, rs1931656, rs3904683, rs10233003, rs11126989, rs9747201, rs6072289, rs11974887, rs6456173, rs7084736, rs1366689, rs77583146, rs9364323, rs11024110, rs13089362, rs869219, rs56921221, rs2910770, rs4889619, rs2605134, rs226456, rs7904473, rs987237, rs78253835, rs62475463, rs2014377, rs67239293, rs11743712, rs75327292, rs7624274, rs149879035, rs6557679, rs7443175, rs16893327, rs764567, rs11245342, rs6527987, rs388738, rs8074740, rs16843274, rs7613548, rs1905339, rs35973557, rs1888344, rs249768, rs35624781, rs1952491, rs11882077, rs7973611, rs73080552, rs448265, rs1776953, rs4537621, rs13138854, rs11645503, rs77016659, rs74454622, rs10510110, rs79177013, rs2246912, rs715299, rs6971448, rs12483377, rs7593009, rs7586187, rs12448432, rs6437582, rs2301742, rs185413393, rs998335, rs145217118, rs140869992, rs2237421, rs4834706

ДОПОЛНИТЕЛЬНЫЕ РЕСУРСЫ:
Зрительная система: как работают ваши глаза (Видео)
Что это за роговица?

В КОТОРОМ ВЫ ТАКЖЕ МОЖЕТЕ БЫТЬ ЗАИНТЕРЕСОВАНЫ:
Толщина роговицы (Шокет, 2020)
Тонкая роговица: Кератоконус (МакКомиш, 2019)
Коэффициент сопротивления роговицы (Симко, 2020)

ЕЖЕНЕДЕЛЬНАЯ ОБНАРУЖИВАЮЩАЯСЯ ДАТА: 27 августа 2020 года


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