WEEKLY UPDATE: August 30, 2019
SUMMARY: Genetic variants linked to inflammation and programmed cell death may affect the risk for ulcerative colitis.
DESCRIPTION: Ulcerative colitis is an inflammatory bowel disease that occurs when sores develop in the colon due to an ongoing inflammation. Symptoms such as diarrhea, abdominal pain, and fatigue typically develop over time. Ulcerative colitis is also known to be heritable, yet the genetic factors underlying this are not well understood. This study examined over 40,000 individuals of European ancestry and discovered 29 novel genetic variants associated with ulcerative colitis. Many of these variants were previously linked to programmed cell death and the immune system, in particular inflammation. The novel variants are estimated to explain 16% of the heritability for ulcerative colitis, with all significant variants explaining 28% of its heritability.
DID YOU KNOW? To reduce ulcerative colitis symptoms, drink plenty of water, limit dairy products and exercise regularly. [SOURCE]