WEEKLY UPDATE: September 26, 2019
STUDY TITLE: Clinical and Genetic Determinants of Varicose Veins
SUMMARY: Identification of 30 novel genetic variants linked with the development of varicose veins.
DESCRIPTION: Varicose veins are a condition characterized by swollen and twisted veins that occurs when blood pools, typically in the legs. Though varicose veins are sometimes considered a cosmetic concern, they can also increase the risk of blood clots. To identify genetic variants that may predispose an individual to varicose veins, this study examined the genomes of over 490,000 individuals of European ancestry. 30 newly discovered genetic loci were correlated with a predisposition to developing varicose veins. Some of these variants are located near genes that play a role in the formation of arteries and veins, while other variants are in proximity to genes that relate to the growth and development of our bones. This study also uncovered a new risk factor for the condition: the taller you are, the greater your risk of developing varicose veins.
DID YOU KNOW? You may be able to prevent or reduce the appearance of varicose veins by exercising regularly, wearing compression stockings during the day, and eating potassium-rich foods such as almonds and leafy vegetables. [SOURCE]
ANALYZED VARIANTS: rs11121615, rs2911463, rs2861819, rs28558138, rs8053350, rs3101725, rs11135046, rs7773004, rs12625547, rs236597, rs7614922, rs73107980, rs7469817, rs2241173, rs816943, rs1061539, rs1549063, rs16828263, rs9719461, rs2263321, rs247749, rs75522736, rs553399706, rs62512472, rs584768, rs2089657, rs12594708, rs186005582, rs192647746