SUMMARY: Identification of over 40 new genetic variants associated with central corneal thickness, which is linked to multiple disorders of the eye.
OVERVIEW: The cornea acts like a “window” for the eye, allowing light to enter while also serving as a barrier against foreign irritants. The thickness of the cornea is a well-studied indicator of eye health, and reduced thickness has been linked to diseases of the eye such as glaucoma. This genome-wide association study aimed to identify genomic regions linked to the thickness at the center of the cornea. By examining the genetic information of over 44,000 individuals of non-Hispanic white, Hispanic, Asian, and African American ethnicity, the study found 98 regions of the genome associated with central corneal thickness. Of these, 41 were novel to this study. Together, all the variants in this study may explain around 14% of individual variation in central corneal thickness. Some of these identified variants were also found to be associated with eye diseases, including keratoconus and glaucoma, underscoring the connections between corneal thickness and disorders of the eye.
DID YOU KNOW? Over 2.5 million eye injuries are recorded each year in the United States alone, with half of them occurring at home. It is highly recommended to wear a properly certified pair of goggles when performing activities involving tools or hazardous chemicals like bleach. [SOURCE]
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CORNEAL THICKNESS-ASSOCIATED VARIANTS: rs28526212, rs3132303, rs121908120, rs12554217, rs930847, rs1931656, rs1828481, rs56009602, rs3132307, rs35809595, rs6910919, rs1831902, rs11111869, rs72755233, rs10471310, rs62279162, rs10980623, rs2034809, rs785429, rs12912010, rs11636578, rs17024437, rs9906577, rs13191376, rs7040970, rs13079175, rs4938174, rs9552680, rs117995094, rs4611262, rs7308752, rs9838430, rs7823059, rs34869, rs56054326, rs7026684, rs4846476, rs166474, rs56223983, rs1412710, rs2731646, rs4475548, rs75550549, rs152446, rs1176321, rs73222243, rs71313931, rs2419835, rs2320163, rs12898341, rs113896694, rs11650127, rs28667150, rs9294963, rs57168185, rs11917483, rs56303154, rs12324079, rs448203, rs62292788, rs96067, rs848546, rs25458, rs10124621, rs6459472, rs4785955, rs7211723, rs3740685, rs10800558, rs11903480, rs4311997, rs10245642, rs154001, rs10943848, rs4623781, rs7737693, rs58671886, rs1800440, rs8133436, rs2505507, rs9350413, rs688601, rs7749695, rs880930, rs117789382, rs13036662, rs35351529, rs28687756, rs3124932, rs11077857, rs9855175
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Keratoconus (McComish, 2019)
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WEEKLY UPDATE: June 25, 2020
